SLC39A5 Antibody (YA8179)
(Synonyms: LZT-Hs7; MYP24; ZIP5)SLC39A5 Antibody (YA8179) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC39A5.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:500-800 |
Product Details
SLC39A5 Antibody (YA8179) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SLC39A5.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 56.1 kDa
Human recombinant protein fragment corresponding to amino acids 48-178 of human SLC39A5 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SLC39A5 is an Uniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine by the uptake of zinc from the blood into the intestine. The transport mechanism is temperature- and concentration-dependent and saturable. In addition, is also a high affinity copper transporter in vitro. Also may regulate glucose-stimulated insulin secretion (GSIS) in islets primarily through the zinc-activated SIRT1-PPARGC1A axis. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera. Plays a role in eye development[1][2].
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Subcellular Localization
Basolateral cell membrane
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Expression
Tissue_Specificity: Expressed in liver, kidney, pancreas, small intestine, colon, spleen, fetal liver and fetal kidney -
Isoforms & Post-Translational Modification
Q6ZMH5: 540 amino acids, molecular weight 56461 Da.
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Subunit
Homodimer
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SwissProt ID
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Synonyms
LZT-Hs7; MYP24; ZIP5
Documentation
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