SOAT2 Antibody (YA8637)
(Synonyms: ACACT2; ACAT2; ARGP2)SOAT2 Antibody (YA8637) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SOAT2.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
SOAT2 Antibody (YA8637) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SOAT2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 59.7 kDa
Human recombinant protein fragment corresponding to amino acids 1-120 of human SOAT2 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SOAT2 catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa |Has lower enzymatic activity compared to isoform 1|Has lower enzymatic activity compared to isoform 1[1][2].
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Subcellular Localization
Endoplasmic reticulum membrane
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Expression
Tissue_Specificity: Expression seems confined in hepatocytes and enterocytes -
Isoforms & Post-Translational Modification
O75908 has four isomers: O75908-1: 59896 Da (predicted); O75908-2: 57614 Da (predicted); O75908-3: 50351 Da (predicted); O75908-4: 34882 Da (predicted).
Polyubiquitinated by AMFR/gp78 at Cys-277, leading to its degradation when the lipid levels are low (PubMed:28604676)丨Oxidized at Cys-277: high concentration of cholesterol and fatty acid induce reactive oxygen species, which oxidizes Cys-277, preventing ubiquitination at the same site, and resulting in protein stabilization -
Subunit
May form homo- or heterodimers (By similarity)
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SwissProt ID
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Synonyms
ACACT2; ACAT2; ARGP2
Documentation
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