SOCS7 Antibody (YA7238)
(Synonyms: NAP4, SOCS6, SOCS7, Suppressor of cytokine signaling 7, SOCS-7, Nck-associated protein 4, NAP-4)
Based on 1 Customer Validation
SOCS7 Antibody (YA7238) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SOCS7.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Formulation:
Supplied in PBS(pH 7.4), 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1000 | 1:100-200 |
Product Details
SOCS7 Antibody (YA7238) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SOCS7.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Observed Molecular WeightObserved band size: 63 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 63 kDa
A synthesized peptide derived from human SOCS 7
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH 7.4), 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SOCS7 is a Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DAB1 and IRS1. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS7) complex acts as a key regulator of reelin signaling by mediating ubiquitination and degradation of phosphorylated DAB1 in the cortical plate of the developing cerebral cortex, thereby regulating neuron positioning during cortex development. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Also inhibits prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA[1][2].
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Subcellular Localization
Cytoplasm,Nucleus,Cell membrane
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Expression
Tissue_Specificity: Expressed in brain and leukocytes (PubMed:9344857). Also in fetal lung fibroblasts and fetal brain (PubMed:9344857)
Induction: By IL6/interleukin-6, prolactin and growth hormone -
Isoforms & Post-Translational Modification
O14512 has two isomers: O14512-1: 62969 Da (predicted); O14512-2: 37461 Da (predicted).
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Subunit
Substrate-recognition component of the ECS(SOCS7) complex, composed of SOCS7, CUL5, ELOB, ELOC and RNF7/RBX2 (PubMed:16127460)
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SwissProt ID
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Synonyms
NAP4, SOCS6, SOCS7, Suppressor of cytokine signaling 7, SOCS-7, Nck-associated protein 4, NAP-4
Documentation
References
[1]. Banks AS, et al. Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans. J Clin Invest. 2005 Sep;115(9):2462-71. [Content Brief]
[2]. Martens N, et al. Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation. J Biol Chem. 2005 Apr 8;280(14):13817-23. [Content Brief]
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