SOX17 Antibody
(Synonyms: FLJ22252, SOX17, SOX17_HUMAN, SRY (sex determining region Y) box 17, SRY box 17, SRY related HMG box transcription factor SOX17, Transcription factor SOX-17, Transcription factor SOX17, VUR3)SOX17 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to SOX17.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IHC-F, IF-Tissue
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Reactivity :
Mouse, Rat
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Formulation:
Supplied in TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-500 | 1:100-500 | 1:100-500 |
Product Details
SOX17 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to SOX17.
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Host Rabbit
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Clonality polyclonal
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Species ReactivityMouse, Rat Predicted Reactivity: Human
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
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Calculated Molecular Weight Predicted band size: 44 kDa;
KLH conjugated synthetic peptide derived from Human SOX17 : 71-180/414
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SOX17 acts as a transcription regulator that binds target promoter DNA. Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development. Required for normal development of the definitive gut endoderm. Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries. Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18. Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis. Probable transcriptional activator in the premeiotic germ cells[1].
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Subcellular Localization
Nucleus
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Expression
Tissue_Specificity: Expressed in adult heart, lung, spleen, testis, ovary, placenta, fetal lung, and kidney. In normal gastrointestinal tract, it is preferentially expressed in esophagus, stomach and small intestine than in colon and rectum. -
Isoforms & Post-Translational Modification
SOX17 has an amino acid length of 414, molecular weight is 44117 Da.
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Subunit
Interacts with CTNNB1, LEF1 and TCF4
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SwissProt ID
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Synonyms
FLJ22252, SOX17, SOX17_HUMAN, SRY (sex determining region Y) box 17, SRY box 17, SRY related HMG box transcription factor SOX17, Transcription factor SOX-17, Transcription factor SOX17, VUR3
Documentation
References
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