SRY Antibody (YA8100)
(Synonyms: SRXX1; SRXY1; TDF; TDY)SRY Antibody (YA8100) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SRY.
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
ICC/IF
-
Reactivity :
Human
-
Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|
| Dilution Ratio | 1:100-250 |
Product Details
SRY Antibody (YA8100) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SRY.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman
-
Calculated Molecular Weight Predicted band size: 23.7 kDa
Full length human recombinant protein of human SRY produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
-
Appearance
Liquid
-
Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
SRY transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3'. SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending. Also involved in pre-mRNA splicing. In male adult brain involved in the maintenance of motor functions of dopaminergic neurons[1][2][3][4][5][6][7][8][9][10].
-
Subcellular Localization
Nucleus speckle,Cytoplasm,Nucleus
-
Isoforms & Post-Translational Modification
Q05066: 204 amino acids, molecular weight 23884 Da.
-
Subunit
Interacts with CALM, EP300, HDAC3, KPNB1, ZNF208 isoform KRAB-O, PARP1, SLC9A3R2 and WT1 (PubMed:12871148, PubMed:12970737, PubMed:15297880, PubMed:15469996, PubMed:15746192, PubMed:16904257, PubMed:9054412)
-
SwissProt ID
-
Synonyms
SRXX1; SRXY1; TDF; TDY
Documentation
Powered by Bioz
