SSB Antibody (YA9778)
(Synonyms: Lupus La protein, La autoantigen, La ribonucleoprotein, Sjoegren syndrome type B antigen, SS-B, SSB)SSB Antibody (YA9778) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to SSB.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IHC-P, IP
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IP
IP: Immunoprecipitation
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|---|---|---|---|
| Dilution Ratio | 1:500-1000 | 1:100-200 | 1:100-200 |
Product Details
SSB Antibody (YA9778) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to SSB.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SSB binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation[1][2][3].
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Subcellular Localization
Nucleus
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Isoforms & Post-Translational Modification
SSB has an amino acid length of 408, molecular weight is 46837 Da.
Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein. -
Subunit
Interacts with DDX15.
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SwissProt ID
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Synonyms
Lupus La protein, La autoantigen, La ribonucleoprotein, Sjoegren syndrome type B antigen, SS-B, SSB
Documentation
References
[1]. Gottlieb E, et al. Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III. EMBO J. 1989 Mar;8(3):851-61. [Content Brief]
[2]. Chambers JC, et al. Genomic structure and amino acid sequence domains of the human La autoantigen. J Biol Chem. 1988 Dec 5;263(34):18043-51. [Content Brief]
[3]. Ray PS, et al. La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA. Nucleic Acids Res. 2002 Oct 15;30(20):4500-8. [Content Brief]
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