STIL/SIL Antibody (YA6781)

Cat. No.: HY-P87088: Data Sheet COA
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STIL/SIL Antibody (YA6781) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STIL/SIL.

For research use only. We do not sell to patients.

Size	Price	Stock
20 μL		Ask For Quote & Lead Time
50 μL		Ask For Quote & Lead Time
100 μL		Ask For Quote & Lead Time

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

STIL/SIL Antibody (YA6781) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STIL/SIL.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 143 kDa;

Observed band size: 175 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q15468

Gene ID

6491 [NCBI]

Immunogen

Recombinant protein within human STIL aa 351-900.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:2000

Purity	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 (PubMed:16024801, PubMed:9372240). Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly (PubMed:22020124). In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292)

Subcellular Localization：Cytoplasm, cytosol,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole,Cytoplasm, cell cortex

Expression：
Tissue_Specificity: Expressed in all hematopoietic tissues and cell lines. Highly expressed in a variety of tumors characterized by increased mitotic activity with highest expression in lung cancer
Induction: Down-regulated when cell proliferation ceased. Accumulates during G2 phase and falls at completion of the cell cycle

Isoforms & Post-Translational Modification：Q15468 has two isomers: Q15468-1: 142955 Da (predicted); Q15468-2: 143042 Da (predicted).
Ubiquitinated丨Phosphorylated following the activation of the mitotic checkpoint

Subunit：Homodimer (PubMed:22020124)

RRID

AB_3719257

Synonyms

DKFZp686O09161 antibody; MCPH7 antibody; OTTHUMP00000009566 antibody; SCL interrupting locus protein antibody; SCL-interrupting locus protein antibody; SCL/TAL1 interrupting locus antibody; SIL antibody; STIL antibody; STIL_HUMAN antibody; TAL 1 interrupting locus protein antibody; DKFZp686O09161 antibody; MCPH7 antibody; OTTHUMP00000009566 antibody; SCL interrupting locus protein antibody; SCL-interrupting locus protein antibody; SCL/TAL1 interrupting locus antibody; SIL antibody; STIL antibody; STIL_HUMAN antibody; TAL 1 interrupting locus protein antibody; TAL-1-interrupting locus protein antibody;

Documentation

Select Batch:

Data Sheet (231 KB) SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)