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STIL/SIL Antibody (YA6781)

(Synonyms: DKFZp686O09161 antibody; MCPH7 antibody; OTTHUMP00000009566 antibody; SCL interrupting locus protein antibody; SCL-interrupting locus protein antibody; SCL/TAL1 interrupting locus antibody; SIL antibody; STIL antibody; STIL_HUMAN antibody; TAL 1 interrupting locus protein antibody; DKFZp686O09161 antibody; MCPH7 antibody; OTTHUMP00000009566 antibody; SCL interrupting locus protein antibody; SCL-interrupting locus protein antibody; SCL/TAL1 interrupting locus antibody; SIL antibody; STIL antibody; STIL_HUMAN antibody; TAL 1 interrupting locus protein antibody; TAL-1-interrupting locus protein antibody; )

STIL/SIL Antibody (YA6781) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STIL/SIL.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Conjugation:
    Non-conjugated
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:2000

Product Details

Description

STIL/SIL Antibody (YA6781) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to STIL/SIL.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 175 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 143 kDa
Immunogen

Recombinant protein within human STIL aa 351-900.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3719257

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    STIL/SIL is an Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CPAP to the base of the procentriole to initiate procentriole assembly. In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility[1][2][3][4][5].

  • Subcellular Localization

    Cytoplasm, cytosol,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole,Cytoplasm, cell cortex

  • Expression


    Tissue_Specificity: Expressed in all hematopoietic tissues and cell lines. Highly expressed in a variety of tumors characterized by increased mitotic activity with highest expression in lung cancer
    Induction: Down-regulated when cell proliferation ceased. Accumulates during G2 phase and falls at completion of the cell cycle

  • Isoforms & Post-Translational Modification

    Q15468 has two isomers: Q15468-1: 142955 Da (predicted); Q15468-2: 143042 Da (predicted).
    Ubiquitinated丨Phosphorylated following the activation of the mitotic checkpoint

  • Subunit

    Homodimer (PubMed:22020124)

  • SwissProt ID

    Q15468

  • Gene ID
    6491 [NCBI]
  • Synonyms

    DKFZp686O09161 antibody; MCPH7 antibody; OTTHUMP00000009566 antibody; SCL interrupting locus protein antibody; SCL-interrupting locus protein antibody; SCL/TAL1 interrupting locus antibody; SIL antibody; STIL antibody; STIL_HUMAN antibody; TAL 1 interrupting locus protein antibody; DKFZp686O09161 antibody; MCPH7 antibody; OTTHUMP00000009566 antibody; SCL interrupting locus protein antibody; SCL-interrupting locus protein antibody; SCL/TAL1 interrupting locus antibody; SIL antibody; STIL antibody; STIL_HUMAN antibody; TAL 1 interrupting locus protein antibody; TAL-1-interrupting locus protein antibody;

STIL/SIL Antibody (YA6781) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • STIL/SIL Antibody (YA6781) Product Image