SXR Antibody
(Synonyms: PXR, NR1I2, Nuclear receptor subfamily 1 group I member 2, Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, Pregnane X receptor, Steroid and xenobiotic receptor, SXR)SXR Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to SXR.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 |
Product Details
SXR Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to SXR.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 53 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 39; 43; 45; 48; 49; 52; 53 kDa
Synthetic peptide of human SXR.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SXR is a Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. Activated by a broad range of endogenous steroids (e.g. pregnenolone, progesterone) and xenobiotics, including the antibiotic rifampicin and certain plant-derived metabolites. Upon ligand binding, translocates to the nucleus, forms a heterodimer with the retinoid X receptor/RXR, and binds to response elements in target promoters, leading to transcriptional activation. Target genes include cytochrome P450 enzymes such as CYP3A4 and ATP-binding cassette transporters including ABCB1/MDR1
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Subcellular Localization
Nucleus; Cytoplasm
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Expression
Tissue_Specificity: Expressed in liver, colon and small intestine. -
Isoforms & Post-Translational Modification
SXR has 7 isoforms, O75469-1: amino acid length is 434, molecular weight is 49762 Da (predicted); O75469-2: amino acid length is 379, molecular weight is 43706 Da (predicted); O75469-3: amino acid length is 457, molecular weight is 52129 Da (predicted); O75469-4: amino acid length is 397, molecular weight is 45766 Da (predicted); O75469-5: amino acid length is 342, molecular weight is 39710 Da (predicted); O75469-6: amino acid length is 420, molecular weight is 48134 Da (predicted); O75469-7: amino acid length is 473, molecular weight is 53899 Da (predicted).Phosphorylated by PKC at Thr-408
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Subunit
Heterodimer with RXR.
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SwissProt ID
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Synonyms
PXR, NR1I2, Nuclear receptor subfamily 1 group I member 2, Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, Pregnane X receptor, Steroid and xenobiotic receptor, SXR
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