Thyroglobulin Antibody (YA9685)
(Synonyms: AITD 3, AITD3, hTG, TDH3, Tg, TGN, THYG_HUMAN, Thyroglobulin)Thyroglobulin Antibody (YA9685) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Thyroglobulin.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IF-Tissue
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Reactivity :
Human
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Formulation:
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|---|
| Dilution Ratio | 1:500 | 1:200 | 1:1000 |
Product Details
Thyroglobulin Antibody (YA9685) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to Thyroglobulin.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 305 kDa;
Recombinant protein of Human Thyroglobulin (aa 2620-2768).
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Thyroglobulin acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen. Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream. One dimer produces 7 thyroid hormone molecules[1][2].
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Subcellular Localization
Secreted
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Expression
Tissue_Specificity: Specifically expressed in the thyroid gland. -
Isoforms & Post-Translational Modification
Thyroglobulin has 2 isoforms, P01266-1: amino acid length is 2768, molecular weight is 304790 Da (predicted); P01266-2: amino acid length is 2711, molecular weight is 298383 Da (predicted).
Iodinated on tyrosine residues by TPO. There are 4 pairs of iodinated tyrosines used for coupling: acceptor Tyr-24 is coupled to donor Tyr-149 or Tyr-234, acceptor Tyr-2573 is coupled to donor Tyr-2540, acceptor Tyr-2766 in monomer 1 is coupled to donor Tyr-2766 in monomer 2 and acceptor Tyr-1310 in monomer 1 is coupled to donor Tyr-108 in monomer 2 -
Subunit
Monomer.
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SwissProt ID
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Synonyms
AITD 3, AITD3, hTG, TDH3, Tg, TGN, THYG_HUMAN, Thyroglobulin
Documentation
References
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