TIPIN Antibody (YA8113)
(Synonyms: FLJ20516)TIPIN Antibody (YA8113) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TIPIN.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
TIPIN Antibody (YA8113) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to TIPIN.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 34.3 kDa
Full length human recombinant protein of human TIPIN produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TIPIN plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress[1][2][3][4][5].
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Subcellular Localization
Cytoplasm,Nucleus
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Isoforms & Post-Translational Modification
Q9BVW5: 301 amino acids, molecular weight 34555 Da.
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Subunit
Interacts with TIMELESS (via N-terminus), which impairs TIMELESS self-association (PubMed:17102137, PubMed:17116885, PubMed:17296725, PubMed:23359676, PubMed:28334766, PubMed:34694004, PubMed:34700328)
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SwissProt ID
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Synonyms
FLJ20516
Documentation
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