Transgelin-2 Antibody
(Synonyms: KIAA0120, CDABP0035, TAGLN2, Transgelin-2, Epididymis tissue protein Li 7e, SM22-alpha homolog)Transgelin-2 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Transgelin-2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-200 |
Product Details
Transgelin-2 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Transgelin-2.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 22 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 22; 24 kDa
Purified recombinant protein of human Transgelin-2
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Transgelin-2 is a Transgelin-2 is an actin-binding protein that is encoded by the TAGLN2 gene in humans and the Tagln2 gene in mice. It is one of the three transgelin isoforms with transgelin-1 (also known as SM22α) and transgelin-3 (NP25). Transgelin-2 is the only transgelin family member expressed in immune cells. It plays pivotal roles in mediating various immune responses, including stabilizing the immune synapse between T cells and antigen-presenting cells (APCs) and potentiating phagocytosis in activated macrophages. Immune cells expressing high levels of transgelin-2 have dynamic membrane structures that facilitate the immune surveillance of the entire body for sensing pathologic insults. Conversely, these molecular characteristics of transgelin-2 in cancer cells may aid tumor metastasis or tissue invasion. In agreement with this, transgelin-2 is considered a potential oncogenic factor in various cancer types[1].
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Expression
Tissue specificity: Expressed in epididymis (at protein level) -
Isoforms & Post-Translational Modification
Transgelin-2 has 2 isoforms: P37802-1: 22,391 Da (predicted); P37802-2: 24,454 Da (predicted).
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SwissProt ID
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Synonyms
KIAA0120, CDABP0035, TAGLN2, Transgelin-2, Epididymis tissue protein Li 7e, SM22-alpha homolog
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