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TRIB1 Antibody (YA8710)(PBS only)

(Synonyms: C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1)

TRIB1 Antibody (YA8710) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIB1.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • TRIB1 Antibody (YA8710)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:150-500

Product Details

Description

TRIB1 Antibody (YA8710) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIB1.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
Immunogen

Full length human recombinant protein of human TRIB1 produced in HEK293T cell.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG1

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    TRIB1 is an Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase. The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain. Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA. Binds selectively the recognition sequence of CEBPA. Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner. Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain. Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity[1][2][3].

  • Expression


    Tissue_Specificity: Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow

  • Isoforms & Post-Translational Modification

    Q96RU8 has two isomers: Q96RU8-1: 41009 Da (predicted); Q96RU8-2: 23473 Da (predicted).

  • Subunit

    Monomer (PubMed:26455797)

  • SwissProt ID

    Q96RU8

  • Synonyms

    C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1

TRIB1 Antibody (YA8710)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • TRIB1 Antibody (YA8710)(PBS only) Product Image