TRIB1 Antibody (YA8710)

Cat. No.: HY-P89026: Data Sheet User Guide for Antibodies
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TRIB1 Antibody (YA8710) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIB1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

TRIB1 Antibody (YA8710) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIB1.

Host

Mouse

Clonality

Monoclonal

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q96RU8

Immunogen

Full length human recombinant protein of human TRIB1 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797)

Expression：
Tissue_Specificity: Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow

Isoforms & Post-Translational Modification：Q96RU8 has two isomers: Q96RU8-1: 41009 Da (predicted); Q96RU8-2: 23473 Da (predicted).

Subunit：Monomer (PubMed:26455797)

Synonyms

C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1

Documentation

User Guide for Antibodies (1077 KB)