TRIB1 Antibody (YA8710)
(Synonyms: C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1)TRIB1 Antibody (YA8710) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIB1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:150-500 |
Product Details
TRIB1 Antibody (YA8710) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIB1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
Full length human recombinant protein of human TRIB1 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TRIB1 is an Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase. The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain. Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA. Binds selectively the recognition sequence of CEBPA. Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner. Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain. Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity[1][2][3].
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Expression
Tissue_Specificity: Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow -
Isoforms & Post-Translational Modification
Q96RU8 has two isomers: Q96RU8-1: 41009 Da (predicted); Q96RU8-2: 23473 Da (predicted).
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Subunit
Monomer (PubMed:26455797)
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SwissProt ID
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Synonyms
C8FW; GIG-2; GIG2; SKIP1; TRB-1; TRB1
Documentation
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