TRIM39 (RNF23) Antibody (YA8219)
(Synonyms: RNF23; TFP; TRIM39B)TRIM39 (RNF23) Antibody (YA8219) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIM39 (RNF23).
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-2000 |
Product Details
TRIM39 (RNF23) Antibody (YA8219) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TRIM39 (RNF23).
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 56.2 kDa
Human recombinant protein fragment corresponding to amino acids 144-378 of human TRIM39 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TRIM39 is an E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation |Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation. Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner[1][2][3][4].
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Subcellular Localization
Cytoplasm, cytosol,Mitochondrion,Nucleus,Nucleus
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Expression
Tissue_Specificity: Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis -
Isoforms & Post-Translational Modification
Q9HCM9 has two isomers: Q9HCM9-1: 59690 Da (predicted); Q9HCM9-2: 56374 Da (predicted).
Autoubiquitinated -
Subunit
Isoform 1 interacts with MOAP1 (PubMed:19100260)
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SwissProt ID
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Synonyms
RNF23; TFP; TRIM39B
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