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TRP2/DCT Antibody (YA1250)

(Synonyms: TRP-2; TRP2; TYRP2; DCT; DT)

TRP2/DCT Antibody (YA1250) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TRP2/DCT.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    IHC-P

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.136.

  • Conjugation:
    Non-conjugated
  • TRP2/DCT Antibody (YA1250) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:100-1:200

Product Details

Description

TRP2/DCT Antibody (YA1250) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TRP2/DCT.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human
  • Observed Molecular Weight
    Observed band size: 60 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 60 kDa
Species Reactivity Database

Entrez Gene: 1638 Human

SwissProt: P40126 Human

Immunogen

Recombinant protein of human TRP2

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.136.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    TRP2/DCT plays a role in melanin biosynthesis. Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA)[1].

  • Subcellular Localization

    Melanosome membrane; Single-pass type I membrane protein; Melanosome

  • Expression


    Induction:Induced by blue light (415nm)

  • Isoforms & Post-Translational Modification

    P40126 has 2 isomers: P40126-1: 59145 Da (predicted); P40126-2: 62929 Da (predicted).
    Glycosylated

  • Subunit

    Forms an OPN3-dependent complex with TYR in response to blue light in melanocytes

  • SwissProt ID

    P40126

  • Gene ID
    1638 [NCBI]
  • Synonyms

    TRP-2; TRP2; TYRP2; DCT; DT

  • Research Field

    Cell Biology

[1]. Pennamen P, et al. Dopachrome tautomerase variants in patients with oculocutaneous albinism. Genet Med. 2021 Mar;23(3):479-487. [Content Brief]

TRP2/DCT Antibody (YA1250) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • TRP2/DCT Antibody (YA1250) Product Image