1. Gene
  2. DCT - dopachrome tautomerase Gene

DCT - dopachrome tautomerase Gene

Homo sapiens

Also known as OCA8; TRP-2; TYRP2

Gene ID: 1638 | Gene type: protein coding

About DCT

Cytogenetic location: 13q32.1 Genomic coordinates (GRCh38): 13:94,436,811-94,549,406 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues, 2 paralogues and is associated with 2 phenotypes. Restricted expression toward skin (RPKM 44.8).

Summary

Predicted to enable dopachrome isomerase activity. Involved in response to blue LIGHT. Located in intracellular membrane-bounded organelle and plasma membrane. Implicated in oculocutaneous albinism. [provided by Alliance of Genome Resources, Apr 2022]

DCT Products(7)

mRNA Protein Name
NM_001129889.3 NP_001123361.1 L-dopachrome tautomerase isoform 2 precursor
NM_001322182.2 NP_001309111.1 L-dopachrome tautomerase isoform 3
NM_001322183.2 NP_001309112.1 L-dopachrome tautomerase isoform 3
NM_001322184.2 NP_001309113.1 L-dopachrome tautomerase isoform 3
NM_001322185.2 NP_001309114.1 L-dopachrome tautomerase isoform 3
NM_001322186.2 NP_001309115.1 L-dopachrome tautomerase isoform 4
NM_001922.5 NP_001913.2 L-dopachrome tautomerase isoform 1 precursor

DCT Protein Structure

Tyrosinase

Tyrosinase: Common central domain of tyrosinase (181 - 408)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 519 a.a.
Protein Preferred Names Protein Names

L-dopachrome tautomerase

DT

Recombinant DCT Proteins

Cat. No. Product Name Accession Purity
HY-P72168 DCT Protein, Human (His-SUMO) P40126 (Q24-T472) ≥95%

Related Diseases

Diseases Alias
Oculocutaneous Albinism, Type Viii

OCA8

Oculocutaneous Albinism Type 8

Albinism, Oculocutaneous, 8

Albinism
Amelanotic Melanoma

Melanoma, Amelanotic

Melanoma Amelanotic

Amelanotic Skin Melanoma

Oculocutaneous Albinism

Albinism, Oculocutaneous

Oca

Albinism Oculocutaneous

Oca - [Oculocutaneous Albinism]

Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1

Vitiligo

VAMAS1

Slev1

Vtlg

Systemic Lupus Erythematosus, Vitiligo-Related

Vitiligo-Associated Multiple Autoimmune Disease 1

Systemic Lupus Erythematosus Vitiligo-Related

Chediak-Higashi Syndrome

CHS

Chédiak-Higashi Syndrome

Chediak - Steinbrinck Anomaly

Chediak Higashi Syndrome

Chediak-Steinbrinck-Higashi Syndrome

Oculocutaneous Albinism With Leukocyte Defect

Chediak-Higashi Disease

Chediak-Higashi-Steinbrink Syndrome

Microphthalmia

Microphthalmos

Isolated Anophthalmia-Microphthalmia Syndrome

Isolated Microphthalmia-Anophthalmia-Coloboma

Simple Microphthalmos

Clinical Anophthalmia

Isolated Anophthalmia - Microphthalmia

Isolated Pure Microphthalmia

Mac Spectrum

Microphthalmia-Anophthalmia-Coloboma Spectrum

Primitive Anophthalmia

Globe Of Eye Small

Small Eyeball

Hypoplasia Of Eye

Isolated Nanophthalmos

Rudimentary Eye

Dysplasia Of Eye

Albinism, Oculocutaneous, Type Iv

OCA4

Oculocutaneous Albinism Type 4

Oculocutaneous Albinism, Type Iv

Oculocutaneous Albinism Type Iv

Albinism, Oculocutaneous, 4

Hermansky-Pudlak Syndrome

Hps

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Hermanski-Pudlak Syndrome

Hermansky Pudlak Syndrome

Platelet Storage Pool Deficiency

Albinism, Oculocutaneous, Type Iii

Rufous Oculocutaneous Albinism

Oculocutaneous Albinism Type 3

OCA3

Roca

Xanthism

Oculocutaneous Albinism Type Iii

Albinism Iii

Oculocutaneous Albinism, Type Iii

Albinism 3

Albinism, Oculocutaneous, Type 3

Rufous Oca

Red Oculocutaneous Albinism

Xanthous Oculocutaneous Albinism

Albinism, Oculocutaneous, 3

Oca-Iii

Albinism, Oculocutaneous, Type Ib

OCA1B

Oculocutaneous Albinism Type 1b

Albinism, Yellow Mutant Type

Yellow Albinism

Oculocutaneous Albinism Type Ib

Temperature-Sensitive Oculocutaneous Albinism Type 1

Oculocutaneous Albinism, Type Ib

Yellow Mutant Albinism

Oca1-Ts

Ts Oca Type 1

Oculocutaneous Albinism, Amish Type

Platinum Oculocutaneous Albinism

Yellow Oculocutaneous Albinism

Albinism, Oculocutaneous, 1b

Albinism Yellow Mutant Type

Oca-Ib

Oca-Its

Oculocutaneous Albinism Type I Temperature-Sensitive

Albinism, Oculocutaneous, Type I, Temperature-Sensitive

Minimal Pigment Oculocutaneous Albinism

Tietz Albinism-Deafness Syndrome

Tietz Syndrome

Albinism-Deafness Of Tietz

Hypopigmentation/Deafness Of Tietz

Tietze'S Syndrome

TADS

Costochondral Junction Syndrome

Costochondritis

Tietze Syndrome

Hypopigmentation-Deafness Syndrome

Costalchondritis

Slipping Rib Syndrome

Tietze'S Disease

Chondropathia Tuberosa

Albinism And Complete Nerve Deafness

Tietz'S Syndrome

Hypopigmentation-Hearing Loss Syndrome

Costal Chondritis

Abnormality Of The Costochondral Junction

Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

Waardenburg'S Syndrome

Waardenburg Syndrome

Van Der Hoeve Halbertsma Waardenburg Gualdi Syndrome

Van Der Hoeve Halbertsona Waardenburg Syndrome

Waardenburg Shah Syndrome

Waardenburg, Types I And/Or Ii

Mende Syndrome

Waardenburgs Syndrome

Waardenburg Syndrome, Type 4a

Waardenburg Syndrome, Type 2a

Waardenburg Syndrome Type 2a

WS2A

Waardenburg Syndrome, Type Iia

Waardenburg Syndrome Without Dystopia Canthorum

Ws2

Waardenburg Syndrome Type Iia

Waardenburg Syndrome 2a

Piebald Trait

Piebaldism

PBT

Partial Albinism

Albinoidism, Oculocutaneous, Autosomal Dominant

Acute Contagious Conjunctivitis

Pink Eye

Contagious Opthalmia

Pinkeye

Conjunctivitis

Keratoconjunctivitis Due To Mycoplasma Conjunctivae

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Melanoma, Cutaneous Malignant 1

Familial Melanoma

Melanoma, Cutaneous Malignant, Susceptibility To, 1

Melanoma, Malignant

CMM1

Melanoma, Cutaneous Malignant

Cmm

Familial Atypical Mole-Malignant Melanoma Syndrome

Fammm

Melanoma, Familial

Mlm

Dysplastic Nevus Syndrome, Hereditary

Dns

B-K Mole Syndrome

Melanoma, Cutaneous Malignant, 1

Malignant Melanoma, Cutaneous

Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

Dysplastic Nevus Syndrome

Cutaneous Melanoma

Familial Atypical Mole Melanoma Syndrome

Hereditary Melanoma

Melanoma, Uveal

Uveal Melanoma

Choroidal Melanoma

Melanoma Of Uvea

Iris Melanoma

Malignant Melanoma Of Choroid

Malignant Melanoma Of Iris

Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Hirschsprung'S Disease

Congenital Megacolon

Congenital Intestinal Aganglionosis

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris DCT VGNC VGNC:39814
Macaca mulatta DCT VGNC VGNC:71749
Bos taurus DCT VGNC VGNC:27926
Rattus norvegicus DCT RGD RGD:1564975
Mus musculus DCT MGD MGI:102563
Felis catus DCT VGNC VGNC:61377
Others DCT NCBI