TrpV5 Antibody (YA7685)
(Synonyms: ECAC1, TRPV5, Transient receptor potential cation channel subfamily V member 5, TrpV5, Calcium transport protein 2, Epithelial calcium channel 1, Osm-9-like TRP channel 3, CaT2, ECaC, ECaC1, OTRPC3)
Based on 1 Customer Validation
TrpV5 Antibody (YA7685) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TrpV5.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IHC-F, IF-Tissue
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-500 | 1:100-500 | 1:100-500 |
Product Details
TrpV5 Antibody (YA7685) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TrpV5.
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Host Rabbit
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Clonality Recombinant
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 90 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 83 kDa
A synthesized peptide derived from human TRPV5: 1-100.
Endogenous
affinity purified by Protein A
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
TrpV5 is a Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating[1][2].
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Subcellular Localization
Apical cell membrane
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Expression
Tissue_Specificity: Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum -
Isoforms & Post-Translational Modification
Q9NQA5 has two isomers: Q9NQA5-1: 82562 Da (predicted); Q9NQA5-2: 43167 Da (predicted).
Glycosylated -
Subunit
Homotetramer and probably heterotetramer with TRPV6
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SwissProt ID
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Synonyms
ECAC1, TRPV5, Transient receptor potential cation channel subfamily V member 5, TrpV5, Calcium transport protein 2, Epithelial calcium channel 1, Osm-9-like TRP channel 3, CaT2, ECaC, ECaC1, OTRPC3
Documentation
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