TSEN34 Antibody (YA8790)

Cat. No.: HY-P89106: Data Sheet User Guide for Antibodies
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TSEN34 Antibody (YA8790) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TSEN34.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

TSEN34 Antibody (YA8790) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to TSEN34.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 33.5 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9BSV6

Immunogen

Full length human recombinant protein of human TSEN34 produced in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events

Subcellular Localization：Nucleus,Nucleus, nucleolus

Isoforms & Post-Translational Modification：Q9BSV6: 310 amino acids, molecular weight 33652 Da.

Subunit：tRNA splicing endonuclease is a heterotetramer composed of TSEN2, TSEN15, TSEN34/LENG5 and TSEN54

Synonyms

LENG5; PCH2C; SEN34; SEN34L

Documentation

User Guide for Antibodies (1077 KB)