UBE2D2 Antibody (YA7873)
(Synonyms: E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B)UBE2D2 Antibody (YA7873) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to UBE2D2.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:1000-4000 | 1:150-500 |
Product Details
UBE2D2 Antibody (YA7873) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to UBE2D2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 16.6 kDa
Full length human recombinant protein of human UBE2D2 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
UBE2D2 is an Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and SQSTM1 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection. Essential for viral activation of IRF3[1][2][3][4][5][6][7][8][9][10][11].
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Isoforms & Post-Translational Modification
P62837 has two isomers: P62837-1: 16735 Da (predicted); P62837-2: 13635 Da (predicted).
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Subunit
Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex
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SwissProt ID
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Synonyms
E2(17)KB2; PUBC1; UBC4; UBC4/5; UBCH4; UBCH5B
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