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Cat. No.: HY-P85824

uPAR Antibody (YA5516)

Name: uPAR Antibody (YA5516)
Brand: MedChemExpress
SKU: HY-P85824
Availability: PreOrder

uPAR Antibody (YA5516) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to uPAR.

For research use only. We do not sell to patients.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:500-2000	1:100-500	1:1000-5000

Description

uPAR Antibody (YA5516) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to uPAR.

Host Mouse
Clonality Monoclonal
Species Reactivity
Human
Observed Molecular Weight

Observed band size: 37 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 37 kDa

Immunogen

Synthesized peptide derived from human uPAR AA range: 100-200

Purification

Protein G

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG2b

Appearance

Liquid
Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

uPAR acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form^[1].
Subcellular Localization

Cell membrane; Cell projection, invadopodium membrane; Cell membrane; Lipid-anchor, GPI-anchor; Secreted
Expression

Tissue_specificity:It is expressed (protein level) in neurons in the central region of the brain. It is expressed in the brain.
Isoforms & Post-Translational Modification

Q03405 has 3 isomers: Q03405-1: 36978 Da (predicted); Q03405-2: 31263 Da (predicted); Q03405-3: 32016 Da (predicted).
Subunit

Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Interacts with FAP (seprase); the interaction occurs at the cell surface of invadopodia membrane. Interacts with SORL1 (via N-terminal ectodomain); this interaction decreases PLAUR internalization (PubMed:14764453, PubMed:23486467). The ternary complex composed of PLAUR-PLAU-SERPINE1 also interacts with SORL1 (PubMed:15053742). Interacts with CD82; this interaction prevents PLAUR from binding to its high affinity ligand PLAU (PubMed:15677461)
SwissProt ID

Q03405
Gene ID

5329 [NCBI]