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USP48 Antibody (YA7808)(PBS only)

(Synonyms: RAP1GA1; USP31)

USP48 Antibody (YA7808) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to USP48.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2a

  • Application:

    WB, IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • USP48 Antibody (YA7808)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:500-2000 1:150-500

Product Details

Description

USP48 Antibody (YA7808) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to USP48.

  • Host Mouse
  • Species Reactivity
    Human, Mouse, Rat
Immunogen

Human recombinant protein fragment corresponding to amino acids 361-743 of human USP48 produced in E.coli.

Purification

Affinity purified

Conjugation

Non-conjugated

Isotype

IgG2a

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    USP48 is a Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins. Plays a role in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Plays an important role in cell cycle progression by deubiquitinating Aurora B/AURKB and thereby extending its stability. In the context of H.pylori infection, stabilizes nuclear RELA through deubiquitination, thereby promoting the transcriptional activity of RELA to prolong TNFAIP3 de novo synthesis. Consequently, TNFAIP3 suppresses caspase activity and apoptotic cell death. Also functions in the modulation of the ciliary and synaptic transport as well as cytoskeleton organization, which are key for photoreceptor function and homeostasis. To achieve this, stabilizes the levels of the retinal degeneration-associated proteins ARL3 and UNC119 using distinct mechanisms. Plays a positive role in pyroptosis by stabilizing gasdermin E/GSDME through removal of its 'Lys-48'-linked ubiquitination[1][2][3][4][5][6].

  • Subcellular Localization

    Cytoplasm,Nucleus,Cell projection, cilium

  • Expression


    Tissue_Specificity: Widely expressed. Expressed in the fetal inner ear (PubMed:34059922)

  • Isoforms & Post-Translational Modification

    Q86UV5 has 8 isomers: Q86UV5-1: 119032 Da (predicted); Q86UV5-2: 112959 Da (predicted); Q86UV5-3: 81449 Da (predicted); Q86UV5-4: 45481 Da (predicted); Q86UV5-5: 59454 Da (predicted); Q86UV5-6: 17094 Da (predicted); Q86UV5-7: 56151 Da (predicted); Q86UV5-8: 120526 Da (predicted).

  • Subunit

    Interacts with TRAF2 and RELA

  • SwissProt ID

    Q86UV5

  • Synonyms

    RAP1GA1; USP31

USP48 Antibody (YA7808)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • USP48 Antibody (YA7808)(PBS only) Product Image