WIBG Antibody (YA8409)
(Synonyms: PYM; WIBG)WIBG Antibody (YA8409) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to WIBG.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ICC/IF
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:100-500 | 1:100-250 |
Product Details
WIBG Antibody (YA8409) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to WIBG.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 22.5 kDa
Full length human recombinant protein of human WIBG produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
WIBG is key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by, while did not detect RNA-binding activity independently of the EJC[1][2].
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Subcellular Localization
Cytoplasm,Nucleus, nucleolus,Nucleus, nucleoplasm
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Isoforms & Post-Translational Modification
Q9BRP8 has two isomers: Q9BRP8-1: 22656 Da (predicted); Q9BRP8-2: 22705 Da (predicted).
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Subunit
Interacts (via N-terminus) with MAGOH and RBM8A; the interaction is direct
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SwissProt ID
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Synonyms
PYM; WIBG
Documentation
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