XPF Antibody (YA7834)
(Synonyms: ERCC11; FANCQ; RAD1; XFEPS; XPF)XPF Antibody (YA7834) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to XPF.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
IHC-P, , ICC/IF
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Reactivity :
Human, Mouse
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|---|
| Dilution Ratio | 1:100-250 | 1:100 | 1:500-800 |
Product Details
XPF Antibody (YA7834) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to XPF.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Calculated Molecular Weight Predicted band size: 104.3 kDa
Full length human recombinant protein of human XPF produced in HEK293 cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
XPF is a Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair
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Subcellular Localization
Nucleus,Chromosome
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Isoforms & Post-Translational Modification
Q92889 has two isomers: Q92889-1: 104486 Da (predicted); Q92889-2: 42745 Da (predicted).
Acetylation at Lys-911 by KAT5 promotes interaction with ERCC1 by disrupting a salt bridge between Glu-907 and Lys-911, thereby exposing a second binding site for ERCC1 (PubMed:32034146) -
Subunit
Heterodimer composed of ERCC1 and ERCC4/XPF (PubMed:10413517, PubMed:16076955, PubMed:16338413, PubMed:25538220, PubMed:32034146)
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SwissProt ID
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Synonyms
ERCC11; FANCQ; RAD1; XFEPS; XPF
Documentation
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