ZEB2 Antibody (YA7746)(PBS only)
(Synonyms: HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B)ZEB2 Antibody (YA7746) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZEB2.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:2000-3000 | 1:150-500 |
Product Details
ZEB2 Antibody (YA7746) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ZEB2.
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Host Mouse
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Species ReactivityHuman, Mouse, Rat
Human recombinant protein fragment corresponding to amino acids 1-350 of human ZEB2 produced in E.coli.
Affinity purified
Non-conjugated
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ZEB2 transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters. Represses transcription of E-cadherin. Represses expression of MEOX2[1][2].
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Subcellular Localization
Nucleus,Chromosome
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Expression
Induction: Down-regulated by microRNA-221 (miR-221)
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Isoforms & Post-Translational Modification
O60315 has two isomers: O60315-1: 136447 Da (predicted); O60315-2: 133806 Da (predicted).
Sumoylation on Lys-391 and Lys-866 is promoted by the E3 SUMO-protein ligase CBX4, and impairs interaction with CTBP1 and transcription repression activity -
Subunit
Binds activated SMAD1, activated SMAD2 and activated SMAD3; binding with SMAD4 is not detected (By similarity)
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SwissProt ID
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Synonyms
HSPC082; SIP-1; SIP1; SMADIP1; ZFHX1B
Documentation
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