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Cat. No.: HY-163808

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Anticancer agent 237

Anticancer agent 237 (compound 13) is a potent anticancer agent. Anticancer agent 237 shows cytotoxicity. Anticancer agent 237 induces apoptosis and cell cycle arrest at the S and G2/M phases.

For research use only. We do not sell to patients.

CAS No.: 17822-61-6
Formula: C₁₈H₂₄N₂O₃S
Molecular Weight:348.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Anticancer agent 237 Chemical Structure

CAS No.: 17822-61-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

Anticancer agent 237 (compound 13) is a potent anticancer agent. Anticancer agent 237 shows cytotoxicity. Anticancer agent 237 induces apoptosis and cell cycle arrest at the S and G2/M phases^[1].

In Vitro

Anticancer agent 237 (compound 13) (48 h) induces apoptosis and cell cycle arrest at the S and G2/M phases in HCT-116, MCF-7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HCT-116, MCF-7 cells
Concentration:

0-100 µM
Incubation Time:

48 h
Result:

Showed cytotoxicity with IC₅₀s of 43.5, 62.4 µM for HCT-116, MCF-7 cells, respectively.

Apoptosis Analysis^[1]

Cell Line:

HCT-116, MCF-7 cells
Concentration:

43.5 for HCT-116 cells, 62.4 for MCF-7 cells µM
Incubation Time:

48 h
Result:

Induced apoptosis with 2.24% of the population being in early apoptosis, 0.58% in late apoptosis, and 6.6% in the necrotic population in MCF-7 cells, led to 45.07% of the population being in early apoptosis, 0.42% in late apoptosis, and 0.02% necrotic population in HCT-116 cells.

Cell Cycle Analysis^[1]

Cell Line:

HCT-116, MCF-7 cells
Concentration:

0-100 µM
Incubation Time:

48 h
Result:

Induced cell cycle arrest at the S and G2/M phases.

Chemical Information

CAS No. 17822-61-6
Molecular Weight 348.46
Formula C₁₈H₂₄N₂O₃S
SMILES

O=S(C1=CC=C(C)C=C1)(NC(NC23CC4CC(C3)CC(C4)C2)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sroor FM, et al. Green, facile synthesis and evaluation of unsymmetrical carbamide derivatives as antimicrobial and anticancer agents with mechanistic insights. Sci Rep. 2024 Jul 4;14(1):15441. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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