COX-2-IN-66
COX-2-IN-66 is a cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 8.43 μM. COX-2-IN-66 reduces release of pro-inflammatory cytokines IL-6 and TNF-α. COX-2-IN-66 exhibits acceptable cellular tolerability, with cytokine-modulating concentrations remaining below its cytotoxic threshold. COX-2-IN-66 can be used for the research of inflammation.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C23H23NO2
- Molecular Weight:345.43
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Biologische Aktivität
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COX-2 8.43 μM (IC50) |
COX-1 32.47 μM (IC50) |
IL-6 |
COX-2-IN-66 (Compound 35e) potently inhibits cell-free COX-2 enzymatic activity with an IC50 of 8.43 μM[1].
COX-2-IN-66 inhibits cell-free COX-1 enzymatic activity with an IC50 of 32.47 μM, yielding a COX-1/COX-2 selectivity index of 3.85[1].
COX-2-IN-66 (3.125-100 μM; 24 h) exhibits cytotoxicity in THP-1 macrophages with an IC50 of 67.9 μM[1].
COX-2-IN-66 (2.1-33.7 μM; 22 h) reduces IL-6 and TNF-α release in LPS (HY-D1056)-stimulated THP-1 macrophages with IC50 values of 35.1 μM and 42.3 μM, respectively, under non-cytotoxic conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:THP-1 macrophages
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Concentration:3.125, 6.25, 25, 50, 100 μM
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Incubation Time:24 h
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Result:Showed a cytotoxic IC50 of 67.9 μM in THP-1 macrophages, which was higher than the concentrations required for cytokine modulation.
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Cell Line:LPS-stimulated THP-1 macrophages
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Concentration:2.1, 4.2, 8.4, 16.8, 33.7 μM; 35.1 μM
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Incubation Time:22 h
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Result:Reduced IL-6 and TNF-α release in a concentration-dependent manner, with estimated IC50 values of 35.1 μM for IL-6 and 42.3 μM for TNF-α.
These concentrations were below the cytotoxic IC50 in THP-1 cells.
Chemical Information
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Molecular Weight 345.43
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Formel C23H23NO2
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SMILES
COC1=CC=C(C(C2=CC=C(C)C=C2)N3CCC4=C3C=CC=C4)C(O)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
COX-2-IN-66 Related Classifications
HY-183288 Related Classifications
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