MAPK1 - mitogen-activated protein kinase 1 Gene

Also Known as ERK; p38; p40; p41; ERK2; ERT1; NS13; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5594

About MAPK1

Cytogenetic location: 22q11.22 Genomic coordinates (GRCh38): 22:21,759,657-21,867,680 (from NCBI)

This gene has 4 transcripts (splice variants), 214 orthologues, 19 paralogues and is associated with 72 phenotypes. Ubiquitous expression in brain (RPKM 63.3), thyroid (RPKM 32.9) and 25 other tissues.

Summary

This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]

MAPK1 Products (2)

mRNA	Protein	Name
NM_002745.5	NP_002736.3	mitogen-activated protein kinase 1
NM_138957.3	NP_620407.1	mitogen-activated protein kinase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables MAP kinase activity	IDA IDA: Inferred from direct assay	38503280	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16627622	GOA
enables phosphatase binding	IPI IPI: Inferred from physical interaction	19494114	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9632734	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	7588608	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in ERBB signaling pathway	IDA IDA: Inferred from direct assay	15133037	GOA
involved in ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	16314496	GOA
involved in androgen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22031296	GOA
involved in cellular response to amino acid starvation	IDA IDA: Inferred from direct assay	11096076	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	15850461	GOA
involved in positive regulation of cholesterol biosynthetic process	IDA IDA: Inferred from direct assay	38503280	GOA
acts upstream of positive regulation of macrophage chemotaxis	IGI IGI: Inferred from genetic interaction	26754294	GOA
acts upstream of positive regulation of macrophage proliferation	IGI IGI: Inferred from genetic interaction	26754294	GOA
involved in positive regulation of peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	16314496	GOA
acts upstream of or within positive regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	21531765	GOA
involved in progesterone receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22031296	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	23184662	GOA
involved in response to epidermal growth factor	IDA IDA: Inferred from direct assay	18794356	GOA
involved in steroid hormone receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22031296	GOA
involved in stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	11096076	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18794356	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18794356	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAPK1 Protein Structure

Pkinase

0
100
200
300
360 a.a.

Protein Preferred Names	Protein Names
mitogen-activated protein kinase 1	MAP kinase 1 MAP kinase 2 MAPK 2 extracellular signal-regulated kinase 2 mitogen-activated protein kinase 2 protein tyrosine kinase ERK2

MAPK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	MAPK1	P28482	SHC1	Homo sapiens	P29353-2	FRET	23584453
Intra	MAPK1	P28482	SHC1	Homo sapiens	P29353-2	SAXS	23584453
Intra	MAPK1	P28482	SHC1	Homo sapiens	P29353-2	ITC	23584453
Intra	MAPK1	P28482	RPS6KA3	Homo sapiens	P51812	Anti Tag CoIP	34591642
Intra	MAPK1	P28482	RPS6KA3	Homo sapiens	P51812	Anti Tag CoIP	33961781
Intra	MAPK1	P28482	RPS6KA3	Homo sapiens	P51812	TAP	23602568
Intra	MAPK1	P28482	RPS6KA3	Homo sapiens	P51812	Anti Tag CoIP	31980649
Intra	MAPK1	P28482	RPS6KA3	Homo sapiens	P51812	Pull Down	32707033
Intra	MAPK1	P28482	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	MAPK1	P28482	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	MAPK1	P28482	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	MAPK1	P28482	ZBTB42	Homo sapiens	B2RXF5	Y2H Array	32296183
Intra	MAPK1	P28482	ZBTB42	Homo sapiens	B2RXF5	Y2H Prey Pooling	32296183
Intra	MAPK1	P28482	DUSP7	Homo sapiens	Q16829	Anti Tag CoIP	33961781
Intra	MAPK1	P28482	a0a384nq31_human	Homo sapiens	A0A384NQ31	Y2H Prey Pooling	32296183
Intra	MAPK1	P28482	a0a384nq31_human	Homo sapiens	A0A384NQ31	Y2H Array	32296183
Intra	MAPK1	P28482	RPS6KA2	Homo sapiens	Q15349	Y2H Array	32296183
Intra	MAPK1	P28482	RPS6KA2	Homo sapiens	Q15349	Anti Tag CoIP	33961781
Intra	MAPK1	P28482	RPS6KA2	Homo sapiens	Q15349	TAP	23602568
Intra	MAPK1	P28482	RPS6KA2	Homo sapiens	Q15349	Validated Y2H	32296183
Intra	MAPK1	P28482	RPS6KA2	Homo sapiens	Q15349	Anti Tag CoIP	35271311
Intra	MAPK1	P28482	RPS6KA2	Homo sapiens	Q15349	Anti Tag CoIP	34591642
Intra	MAPK1	P28482	RPS6KA2	Homo sapiens	Q15349	Y2H Prey Pooling	32296183
Intra	MAPK1	P28482	PTPRR	Homo sapiens	Q15256-5	Validated Y2H	32296183
Intra	MAPK1	P28482	PTPRJ	Homo sapiens	Q12913	Anti Tag CoIP	19494114
Intra	MAPK1	P28482	PTPRJ	Homo sapiens	Q12913	Pull Down	19494114
Intra	MAPK1	P28482	PTPRJ	Homo sapiens	Q12913	Peptide Array	19494114
Intra	MAPK1	P28482	PTPRJ	Homo sapiens	Q12913	Phosphatase Assay	19494114
Intra	MAPK1	P28482	PTPRR	Homo sapiens	Q15256	PLA	25241761
Intra	MAPK1	P28482	PTPN7	Homo sapiens	P35236	Phosphatase Assay	10415025
Intra	MAPK1	P28482	PPP1R18	Homo sapiens	Q6NYC8	Validated Y2H	32296183
Intra	MAPK1	P28482	PLAGL2	Homo sapiens	Q9UPG8	Y2H Prey Pooling	32296183
Intra	MAPK1	P28482	PLAGL2	Homo sapiens	Q9UPG8	Y2H Array	32296183
Intra	MAPK1	P28482	PLAGL2	Homo sapiens	Q9UPG8	Validated Y2H	32296183
Intra	MAPK1	P28482	POLR2G	Homo sapiens	P62487	Validated Y2H	32296183
Intra	MAPK1	P28482	POLR2G	Homo sapiens	P62487	Y2H Array	32296183
Intra	MAPK1	P28482	POLR2G	Homo sapiens	P62487	Y2H Prey Pooling	32296183
Intra	MAPK1	P28482	PSMA1	Homo sapiens	P25786	Y2H Array	32296183
Intra	MAPK1	P28482	PSMA1	Homo sapiens	P25786	Y2H Prey Pooling	32296183
Intra	MAPK1	P28482	RNF8	Homo sapiens	O76064	Y2H Array	32296183
Intra	MAPK1	P28482	RNF8	Homo sapiens	O76064	Y2H Prey Pooling	32296183
Intra	MAPK1	P28482	DUSP9	Homo sapiens	Q99956	Anti Tag CoIP	33961781
Intra	MAPK1	P28482	DUSP9	Homo sapiens	Q99956	Anti Tag CoIP	31980649
Intra	MAPK1	P28482	MAP2K1	Homo sapiens	Q02750	Anti Bait CoIP	17255949
Intra	MAPK1	P28482	MSX2	Homo sapiens	P35548	Y2H Array	32296183
Intra	MAPK1	P28482	MSX2	Homo sapiens	P35548	Y2H Prey Pooling	32296183
Intra	MAPK1	P28482	MSX2	Homo sapiens	P35548	Validated Y2H	32296183
Intra	MAPK1	P28482	DUSP4	Homo sapiens	Q13115	Anti Tag CoIP	31980649
Intra	MAPK1	P28482	DUSP4	Homo sapiens	Q13115	Validated Y2H	32296183
Intra	MAPK1	P28482	MAPK14	Homo sapiens	Q16539-3	Anti Bait CoIP	22521293
Intra	MAPK1	P28482	MAPK14	Homo sapiens	Q16539-3	Anti Tag CoIP	17255949
Intra	MAPK1	P28482	MAPK14	Homo sapiens	Q16539-3	PLA	22521293
Intra	MAPK1	P28482	PEA15	Homo sapiens	Q15121	Y2H Prey Pooling	32296183
Intra	MAPK1	P28482	PEA15	Homo sapiens	Q15121	Validated Y2H	32296183
Intra	MAPK1	P28482	PEA15	Homo sapiens	Q15121	Y2H Array	32296183
Intra	MAPK1	P28482	TRAPPC4	Homo sapiens	Q9Y296	Pull Down	21826244
Intra	MAPK1	P28482	TRAPPC4	Homo sapiens	Q9Y296	Y2H	21826244
Intra	MAPK1	P28482	TRAPPC4	Homo sapiens	Q9Y296	Anti Tag CoIP	21826244
Intra	MAPK1	P28482	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	MAPK1	P28482	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	MAPK1	P28482	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	MAPK1	P28482	MKNK1	Homo sapiens	Q9BUB5	Anti Tag CoIP	31980649
Intra	MAPK1	P28482	MKNK1	Homo sapiens	Q9BUB5	MAPPIT	32296183
Intra	MAPK1	P28482	MKNK1	Homo sapiens	Q9BUB5	Y2H Prey Pooling	32296183
Intra	MAPK1	P28482	MKNK1	Homo sapiens	Q9BUB5	Y2H Array	32296183
Intra	MAPK1	P28482	MKNK1	Homo sapiens	Q9BUB5	Anti Tag CoIP	33961781
Intra	MAPK1	P28482	MKNK1	Homo sapiens	Q9BUB5	Validated Y2H	32296183
Intra	MAPK1	P28482	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	32296183
Intra	MAPK1	P28482	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
Intra	MAPK1	P28482	LZTS2	Homo sapiens	Q9BRK4	Anti Tag CoIP	31980649
Intra	MAPK1	P28482	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
Intra	MAPK1	P28482	DUSP6	Homo sapiens	Q16828	CoIP	12840032
Intra	MAPK1	P28482	DUSP6	Homo sapiens	Q16828	Anti Tag CoIP	18060821
Intra	MAPK1	P28482	DUSP5	Homo sapiens	Q16690	Y2H	15713638
Cross	MAPK1	P28482	Dusp2	Mus musculus	Q05922	Pull Down	16288922
Intra	MAPK1	P28482	RPS6KA1	Homo sapiens	Q15418	Anti Tag CoIP	33961781
Intra	MAPK1	P28482	RPS6KA1	Homo sapiens	Q15418	BRET	29997244
Intra	MAPK1	P28482	RPS6KA1	Homo sapiens	Q15418	Anti Tag CoIP	34591642
Intra	MAPK1	P28482	RPS6KA1	Homo sapiens	Q15418	Anti Tag CoIP	31980649
Intra	MAPK1	P28482	RPS6KA1	Homo sapiens	Q15418	Lumier	32814053
Intra	MAPK1	P28482	STXBP1	Homo sapiens	P61764	Validated Y2H	32296183
Intra	MAPK1	P28482	DUSP1	Homo sapiens	P28562	Protein Kinase Assay	16286470
Intra	MAPK1	P28482	DUSP1	Homo sapiens	P28562	Pull Down	16286470
Intra	MAPK1	P28482	PPM1A	Homo sapiens	P35813	Phosphatase Assay	23560844
Cross	MAPK1	P28482	MBP	Bos taurus	P02687	Protein Kinase Assay	18616943
Cross	MAPK1	P28482	MBP	Bos taurus	P02687	Protein Kinase Assay	9632734
Cross	MAPK1	P28482	cic	Drosophila melanogaster	Q9U1H0	Y2H	17255944
Cross	MAPK1	P28482	cic	Drosophila melanogaster	Q9U1H0	Protein Kinase Assay	17255944

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAPK1 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P75223	MAPK1/ERK2 Protein, Human (Active, sf9, His)	P28482-1 (M1-S360)	≥ 95%, as determined by reducing SDS-PAGE.

MAPK1 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80392	Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Antibody (YA455)	WB, IHC-P, ICC/IF, IP, FC, IF-Tissue	Human, Mouse, Rat
HY-P80393	ERK1/2 Antibody (YA453)	WB, ICC/IF, IP, FC	Human, Mouse, Rat
HY-P80394	ERK2 Antibody (YA452)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse, Rat
HY-P80813	Phospho-ERK1/2 (Thr202/Thr185) Antibody (YA200)	WB, IP	Human, Hamster, Rat
HY-P80813A	Phospho-ERK1/2 (Thr202/Thr185) Antibody (YA200)(PBS only)	WB, IP	Human, Hamster, Rat
HY-P80814	Phospho-ERK1/2 (Thr202/Tyr204)/(Thr185/Tyr187) Antibody	WB	Human, Mouse, Rat
HY-P80815	Phospho-ERK1/2 (Tyr204/Tyr187) Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P84236	ERK2 Antibody (YA3933)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Monkey
HY-P84236A	ERK2 Antibody (YA3933)(PBS only)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse, Monkey
HY-P84237	ERK1/2 Antibody (YA3934)	IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rabbit
HY-P84237A	ERK1/2 Antibody (YA3934)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rabbit
HY-P85629	Phospho-ERK1/2(Thr202/Tyr204) Antibody (YA5321)	WB	Human, Mouse
HY-P85770	ERK 1/2 Antibody (YA5462)	WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P85835	ERK2 Antibody (YA5527)	WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P86068	Phospho-ERK 1/2(Y222/205) Antibody (YA5760)	IHC-P, ICC/IF	Human, Rat, Mouse
HY-P86225	Phospho-Erk 1/2(Thr202/Tyr204) Antibody (YA5917)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86387	ERK1/2 Antibody (YA6079)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Specific Learning Disability	Specific Learning Difficulty Specific Learning Disorder
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Pertussis	Whooping Cough Bordetella Infections Bordetella Infection Bordetella Pertussis Infection Wc - Whooping Cough Whooping Cough Due To Unspecified Organism Bordetellosis Tussis Convulsiva Whooping Cough, Unspecified Organism Wc - [Whooping Cough] Whooping Cough Due To B. Parapertussis Infection Due To Bordetella Parapertussis
Vagus Nerve Disease	Vagus Nerve Diseases Disorder Of Pneumogastric [10th] Nerve Disorder Of Vagal Nerve Disorder Of Vagus Nerve Vagus Nerve Disorder Disorders Of The Tenth Cranial Nerve Disorders Of 10th Cranial Nerve Disorder Of Pneumogastric Nerve
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Microphthalmia	Microphthalmos Isolated Anophthalmia-Microphthalmia Syndrome Isolated Microphthalmia-Anophthalmia-Coloboma Simple Microphthalmos Clinical Anophthalmia Isolated Anophthalmia - Microphthalmia Isolated Pure Microphthalmia Mac Spectrum Microphthalmia-Anophthalmia-Coloboma Spectrum Primitive Anophthalmia Globe Of Eye Small Small Eyeball Hypoplasia Of Eye Isolated Nanophthalmos Rudimentary Eye Dysplasia Of Eye
Thyroid Gland Anaplastic Carcinoma	Anaplastic Thyroid Carcinoma Anaplastic Thyroid Cancer Thyroid Cancer, Anaplastic Thyroid Carcinoma, Anaplastic Thyroid Carcinoma Anaplastic
Adenocarcinoma	Adenocarcinomas Adenoacanthoma Of Unspecified Site Adenocarcinoid Of Unspecified Site Adenocarcinoid Tumour Of Unspecified Site Adenocarcinoma And Carcinoid Combined Of Unspecified Site Adenocarcinoma Nos
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Chromosome 22q11.2 Deletion Syndrome, Distal	22q11.2 Deletion Syndrome Autosomal Dominant Opitz G/Bbb Syndrome Catch22 Cayler Cardiofacial Syndrome Conotruncal Anomaly Face Syndrome Digeorge Syndrome Sedlackova Syndrome Shprintzen Syndrome Velocardiofacial Syndrome Distal 22q11.2 Microdeletion Syndrome 22q11.2ds Vcfs Velo-Cardio-Facial Syndrome Distal Chromosome 22q11.2 Deletion Syndrome Chromosome 22q11.2 Deletion Syndrome Distal 22q11.2 Distal Deletion Syndrome Chromosome 22q11.2 Deletion Syndrome Deletion 22q11.2 Syndrome 22q11ds Catch 22 Digeorge Sequence Microdeletion 22q11.2 Monosomy 22q11 Takao Syndrome Distal Del(22)(Q11.2) Distal Monosomy 22q11.2 Catch 22 Syndrome Chromosome Deletion Syndrome 22q11.2 ,Distal
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Skin Carcinoma	Skin Cancer Carcinoma Of Skin Ca - Skin Cancer Cancer Of Skin Malignant Neoplasm Of Skin Melanoma And Non-Melanoma Skin Cancer Skin Cancers Cancer, Skin
Diffuse Large B-Cell Lymphoma	Dlbcl Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Large B-Cell Diffuse Lymphoma Lymphoma, Large B-Cell, Diffuse Dlbcl - [Diffuse Large B-Cell Lymphoma] Diffuse Large Beta Cell Lymphoma
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy, Hypertrophic, Familial Familial Hypertrophic Cardiomyopathy Cardiomyopathy Hypertrophic Obstructive Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Insulin-Like Growth Factor I	Insulin-Like Growth Factor I Deficiency IGF1 DEFICIENCY Insulin-Like Growth Factor I, Resistance To Growth Retardation With Deafness And Mental Retardation Due To Igf1 Deficiency Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency Growth Delay Due To Insulin-Like Growth Factor I Resistance IGF1RES Igf-I Resistance Growth Retardation With Sensorineural Deafness And Mental Retardation Somatomedin, End-Organ Insensitivity To Somatomedin-C Somatomedin-C, Resistance To Insulin-Like Growth Factor 1 Resistance To Igf-1 Resistance Somatomedin End-Organ Insensitivity To Somatomedin-C Resistance To Growth Delay-Deafness-Intellectual Disability Syndrome Growth Delay-Hearing Loss-Intellectual Disability Syndrome Igf-1 Deficiency Primary Insulin-Like Growth Factor Deficiency Resistance To Igf-1 Insulin-Like Growth Factor 1 Resistance End-Organ Insensitivity To Somatomedin Igf1 Resistance Resistance To Insulin-Like Growth Factor I Resistance To Somatomedin-C Insulin-Like Growth Factor 1, Resistance To
Rasopathy	Ras/Mitogen-Activated Protein Kinase Syndrome
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Cervical Cancer	Cervical Cancer, Somatic Neoplasm Of Uterine Cervix Cervix Cancer Uterine Cervical Neoplasm Cervical Neoplasm Cervix Uteri Cancer Tumor Of The Cervix Uteri CERCA Uterine Cervical Cancer Neoplasms Cervical Uterine Cervical Neoplasms Cervical Cancers Cancer, Cervical, Somatic Malignant Tumor Of Cervix Cervix Carcinoma
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Prion Disease	Spongiform Encephalopathy Transmissible Spongiform Encephalopathies Prion Diseases Prion Disease Pathway Transmissible Spongiform Encephalopathy Prion Induced Disorder Prion Protein Disease Inherited Human Transmissible Spongiform Encephalopathies Prion Protein Diseases Prion-Associated Disorders Prion-Induced Disorders Transmissible Dementias Tses Human Prion Disease Tse Encephalopathy, Transmissible Spongiform Prion Disease, Susceptibility To Spongiform Encephalopathies Human Transmissible Spongiform Encephalopathies, Inherited
Hyperinsulinism	Hyperinsulinemia
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Cardiomyopathy, Familial Hypertrophic, 25	Hypertrophic Cardiomyopathy 25 CMH25 Cardiomyopathy, Hypertrophic, 25 Cardiomyopathy Familial Hypertrophic 25 Cardiomyopathy, Familial Hypertrophic 25 Cardiomyopathy, Hypertrophic, Type 25
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Head And Neck Cancer Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Cancer, Head/Neck Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Human Cytomegalovirus Infection	Cytomegalovirus Infection Cytomegalovirus Infections
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Chondrosarcoma	Cartilaginous Cancer Chondrosarcoma Of Bone Primary Chondrosarcoma Of The Bone CHDSA
Heart, Malformation Of
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Tuberous Sclerosis	Tuberous Sclerosis Syndrome Bourneville'S Disease Epiloia Cerebral Sclerosis Tuberose Sclerosis Tuberous Sclerosis 1 Bourneville Disease Bourneville Phakomatosis Pringle'S Disease
Bladder Urothelial Carcinoma	Bladder Transitional Cell Carcinoma Transitional Cell Carcinoma Of Bladder Transitional Cell Carcinoma Of The Bladder Urinary Bladder Urothelial Carcinoma Urothelial Bladder Carcinoma Carcinoma Transitional Cell Bladder Tcc - [Transitional Cell Carcinoma] Of Bladder
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Congenital Anomaly Of Heart Heart Defect Heart Malformation Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Glioma
Rhabdomyosarcoma
Cholangiocarcinoma	Cholangiocarcinoma, Susceptibility To Extrahepatic Cholangiocarcinoma Intrahepatic Cholangiocarcinoma Chlc Chlc, Susceptibility To Cc Cholangiocarcinoma Of Biliary Tract Cholangiocellular Carcinoma Distal Cholangiocarcinoma Perihilar Cholangiocarcinoma Bile Duct Cancer Cca Adult Primary Cholangiocellular Carcinoma Bile Duct Carcinoma
Pancreatic Adenocarcinoma	Adenocarcinoma Of Pancreas Adenocarcinoma Of The Pancreas Pancreas Adenocarcinoma Malignant Exocrine Neoplasm Primary Pancreatic Adenocarcinoma Adenocarcinoma Of Islet Cell Of Pancreas Islet Cell Adenocarcinoma Of Unspecified Site Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site
Pediculus Humanus Corporis Infestation	Body Louse Infestation Pediculus Corporis Pediculus Humanus Infestation
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma Primitive Neuroectodermal Tumor ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Ewing Family Of Tumors Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Fibrosarcoma	Neoplasms, Fibrous Tissue Fibrocytic Tumor Fibrosarcoma Of Soft Tissue Fibrous Tissue Neoplasm
Diabetes Mellitus	Diabetes
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Acrodermatitis Chronica Atrophicans	Acrodermatitis Atrophicans Chronica Herxheimer Disease Primary Diffuse Atrophy
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Noonan Syndrome 13	NS13
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Spinal Cord Vascular Diseases Vascular Tissue Disease Vascular Anomaly
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (23)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-13285	Ki16425		99.14%	Unkown
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-N2484	Methylnissolin	Inhibitor	99.92%	Unkown
HY-P2456	MBP MAPK Substrate		99.58%	Unkown
HY-N0363	(+)-Columbianetin		99.04%	Unkown
HY-113788	PF-719		99.52%	Unkown
HY-N0363A	(+)-Columbianetin acetate		99.83%	Unkown
HY-149921	Antiangiogenic agent 3	Inhibitor	/	Unkown
HY-152087	DCZ19931	Inhibitor	/	Unkown
HY-172787	FGFR4-IN-23	Inhibitor	/	Unkown
HY-184145	AKT1-IN-13		/	Unkown
HY-E70844	MAP2K2 Recombinant Human Active Protein Kinase		/	Unkown
HY-N12726	Halociline	Inhibitor	/	Unkown
HY-N17458	N-Acetyldehydroanonaine	Ligand	/	Unkown
HY-N3487	Isodorsmanin A		/	Unkown
HY-P0141	Akt/SKG Substrate Peptide		/	Unkown
HY-P0141A	Akt/SKG Substrate Peptide TFA		/	Unkown
HY-RS08092	MAPK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08093	Mapk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08094	Mapk1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS08115	Mapk3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N0363AR	(+)-Columbianetin acetate (Standard)		/	Unkown
HY-N0363R	(+)-Columbianetin (Standard)		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MAPK1	VGNC	VGNC:31212
Canis familiaris	MAPK1	VGNC	VGNC:42991
Rattus norvegicus	MAPK1	RGD	RGD:70500
Mus musculus	MAPK1	MGD	MGI:1346858
Macaca mulatta	MAPK1	VGNC	VGNC:74641
Felis catus	MAPK1	VGNC	VGNC:68163
Others	MAPK1	NCBI