DUSP5 - dual specificity phosphatase 5 Gene

Homo sapiens

Also known as DUSP; HVH3

Gene ID: 1847 | Gene type: protein coding

About DUSP5

Cytogenetic location: 10q25.2 Genomic coordinates (GRCh38): 10:110,497,907-110,511,533 (from NCBI)

This gene has 2 transcripts (splice variants), 203 orthologues and 30 paralogues. Broad expression in esophagus (RPKM 53.4), gall bladder (RPKM 35.1) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the dual specificity protein Phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008]

DUSP5 Products(1)

mRNA	Protein	Name
NM_004419.4	NP_004410.3	dual specificity protein phosphatase 5

DUSP5 Protein Structure

Rhodanese

DSPc

0
100
200
300
384 a.a.

Protein Preferred Names

Protein Names

dual specificity protein phosphatase 5

VH1-like phosphatase 3

Related Diseases

Diseases

Alias

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma	Gastric Lymphoma, Primary
Lymphoma, Malt, Somatic	Mucosa-Associated Lymphoid Tissue Lymphoma
Extranodal Marginal Zone B-Cell Lymphoma	MALTOMA
Marginal Zone B-Cell Lymphoma	Mucosa-Associated Lymphatic Tissue Lymphoma
Primary Gastric Lymphoma	Gastric Lymphoma
Familial Primary Gastric Lymphoma

Autosomal Recessive Nonsyndromic Deafness 32

Deafness, Autosomal Recessive 32	Autosomal Recessive Deafness 105
Autosomal Recessive Deafness 32	Dfnb32
Hearing Impairment Infertile Male Syndrome	Hiims
Deafness, Autosomal Recessive, Type 32

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04066	DUSP5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DUSP5	VGNC	VGNC:106038
Bos taurus	DUSP5	VGNC	VGNC:28261
Rattus norvegicus	DUSP5	RGD	RGD:620854
Mus musculus	DUSP5	MGD	MGI:2685183
Canis familiaris	DUSP5	VGNC	VGNC:40134

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