DUSP5 - dual specificity phosphatase 5 Gene

Also Known as DUSP; HVH3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1847

About DUSP5

Cytogenetic location: 10q25.2 Genomic coordinates (GRCh38): 10:110,497,907-110,511,533 (from NCBI)

This gene has 2 transcripts (splice variants), 203 orthologues and 30 paralogues. Broad expression in esophagus (RPKM 53.4), gall bladder (RPKM 35.1) and 22 other tissues.

Summary

The protein encoded by this gene is a member of the dual specificity protein Phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, is expressed in a variety of tissues with the highest levels in pancreas and brain, and is localized in the nucleus. [provided by RefSeq, Jul 2008]

DUSP5 Products (1)

mRNA	Protein	Name
NM_004419.4	NP_004410.3	dual specificity protein phosphatase 5

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatase activity	IDA IDA: Inferred from direct assay	24531476	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15713638	GOA
enables protein tyrosine/serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	7961985	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in dephosphorylation	IDA IDA: Inferred from direct assay	24531476	GOA
involved in peptidyl-threonine dephosphorylation	IDA IDA: Inferred from direct assay	7961985	GOA
involved in peptidyl-tyrosine dephosphorylation	IDA IDA: Inferred from direct assay	7961985	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUSP5 Protein Structure

Rhodanese

DSPc

0
100
200
300
384 a.a.

Protein Preferred Names	Protein Names
dual specificity protein phosphatase 5	VH1-like phosphatase 3

DUSP5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DUSP5	Q16690	MAPK1	Homo sapiens	P28482	IF	15713638
Intra	DUSP5	Q16690	MAPK1	Homo sapiens	P28482	Pull Down	15713638

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Lymphoma, Mucosa-Associated Lymphoid Type	Malt Lymphoma Gastric Lymphoma, Primary Lymphoma, Malt, Somatic Mucosa-Associated Lymphoid Tissue Lymphoma Extranodal Marginal Zone B-Cell Lymphoma MALTOMA Marginal Zone B-Cell Lymphoma Mucosa-Associated Lymphatic Tissue Lymphoma Primary Gastric Lymphoma Gastric Lymphoma Familial Primary Gastric Lymphoma
Autosomal Recessive Nonsyndromic Deafness 32	Deafness, Autosomal Recessive 32 Autosomal Recessive Deafness 105 Autosomal Recessive Deafness 32 Dfnb32 Hearing Impairment Infertile Male Syndrome Hiims Deafness, Autosomal Recessive, Type 32

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-202699	SHOC2-RAS PPI-IN-1	Inhibitor	99.50%	Unkown
HY-RS04066	DUSP5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19431	Dusp5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25922	Dusp5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DUSP5	VGNC	VGNC:106038
Bos taurus	DUSP5	VGNC	VGNC:28261
Rattus norvegicus	DUSP5	RGD	RGD:620854
Mus musculus	DUSP5	MGD	MGI:2685183
Canis familiaris	DUSP5	VGNC	VGNC:40134
Others	DUSP5	NCBI