ISG15 - ISG15 ubiquitin like modifier Gene

Also Known as G1P2; IP17; UCRP; IFI15; IMD38; hUCRP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9636

About ISG15

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,013,497-1,014,540 (from NCBI)

This gene has 3 transcripts (splice variants), 223 orthologues, 10 paralogues and is associated with 2 phenotypes. Broad expression in salivary gland (RPKM 43.3), spleen (RPKM 35.3) and 22 other tissues.

Summary

The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and Antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]

ISG15 Products (1)

mRNA	Protein	Name
NM_005101.4	NP_005092.1	ubiquitin-like protein ISG15

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables integrin binding	IPI IPI: Inferred from physical interaction	29100055	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein tag activity	IDA IDA: Inferred from direct assay	16407192	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in ISG15-protein conjugation	IDA IDA: Inferred from direct assay	16122702	GOA
involved in ISG15-protein conjugation	IMP IMP: Inferred from mutant phenotype	22859821	GOA
involved in defense response to bacterium	IMP IMP: Inferred from mutant phenotype	22859821	GOA
involved in defense response to virus	IDA IDA: Inferred from direct assay	33727702	GOA
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	19357168	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	28724761	GOA
involved in integrin-mediated signaling pathway	IDA IDA: Inferred from direct assay	29100055	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	18305167	GOA
involved in negative regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	28724761	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	33727702	GOA
involved in negative regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	19357168	GOA
involved in positive regulation of interferon-beta production	IDA IDA: Inferred from direct assay	33727702	GOA
involved in positive regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	29100055	GOA
involved in positive regulation of protein oligomerization	IDA IDA: Inferred from direct assay	33727702	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	29100055	GOA
involved in protein localization to mitochondrion	IDA IDA: Inferred from direct assay	33727702	GOA
involved in regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	22859821	GOA
involved in response to type I interferon	IDA IDA: Inferred from direct assay	22859821	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	33727702	GOA
involved in response to virus	IEP IEP: Inferred from expression pattern	28724761	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in extracellular region	IDA IDA: Inferred from direct assay	22859821	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ISG15 Protein Structure

ubiquitin

0
100
165 a.a.

Protein Preferred Names	Protein Names
ubiquitin-like protein ISG15	interferon, alpha-inducible protein (clone IFI-15K)

ISG15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Cross	ISG15	P05161	P0C6X7-PRO_0000037311	Human SARS coronavirus	P0C6X7-PRO_0000037311	Anti Tag CoIP	32726803
Cross	ISG15	P05161	P0C6X7-PRO_0000037311	Human SARS coronavirus	P0C6X7-PRO_0000037311	Cleavage	32726803
Cross	ISG15	P05161	P0DTD1-PRO_0000449621	SARS-CoV-2	P0DTD1-PRO_0000449621	Cleavage	32726803
Cross	ISG15	P05161	P0DTD1-PRO_0000449621	SARS-CoV-2	P0DTD1-PRO_0000449621	Probe Interaction	34663977
Cross	ISG15	P05161	P0DTD1-PRO_0000449621	SARS-CoV-2	P0DTD1-PRO_0000449621	Protease Assay	32428392
Cross	ISG15	P05161	P0DTD1-PRO_0000449621	SARS-CoV-2	P0DTD1-PRO_0000449621	Protease Assay	32428392
Cross	ISG15	P05161	P0DTD1-PRO_0000449621	SARS-CoV-2	P0DTD1-PRO_0000449621	Cleavage	32428392
Cross	ISG15	P05161	P0DTD1-PRO_0000449621	SARS-CoV-2	P0DTD1-PRO_0000449621	Cleavage	32428392
Cross	ISG15	P05161	P0DTD1-PRO_0000449621	SARS-CoV-2	P0DTD1-PRO_0000449621	Protease Assay	34270554
Cross	ISG15	P05161	orf1ab	Human betacoronavirus	K0BWD0	Protease Assay	28931677
Cross	ISG15	P05161	orf1ab	Human betacoronavirus	K0BWD0	ITC	28931677
Cross	ISG15	P05161	P0C6U8-PRO_0000338257	Human SARS coronavirus	P0C6U8-PRO_0000338257	ITC	30644842
Cross	ISG15	P05161	P0C6U8-PRO_0000338257	Human SARS coronavirus	P0C6U8-PRO_0000338257	X-Ray Diffraction	28438633
Intra	ISG15	P05161	IRF3	Homo sapiens	Q14653	Anti Bait CoIP	32726803
Intra	ISG15	P05161	FLNB	Homo sapiens	O75369	Pull Down	19270716
Intra	ISG15	P05161	FLNB	Homo sapiens	O75369	Anti Bait CoIP	19270716
Intra	ISG15	P05161	FLNB	Homo sapiens	O75369	Anti Tag CoIP	19270716
Intra	ISG15	P05161	USP18	Homo sapiens	Q9UMW8	Y2H Array	31515488
Intra	ISG15	P05161	USP18	Homo sapiens	Q9UMW8	Validated Y2H	25416956
Intra	ISG15	P05161	USP18	Homo sapiens	Q9UMW8	Y2H Pooling	16189514
Intra	ISG15	P05161	USP18	Homo sapiens	Q9UMW8	Validated Y2H	32296183
Intra	ISG15	P05161	USP18	Homo sapiens	Q9UMW8	Y2H Array	25416956
Intra	ISG15	P05161	UBA7	Homo sapiens	P41226	Y2H Prey Pooling	25416956
Intra	ISG15	P05161	UBA7	Homo sapiens	P41226	Validated Y2H	32296183
Cross	ISG15	P05161	K9N7C7-PRO_0000422441	Middle East respiratory syndrome-related coronavirus	K9N7C7-PRO_0000422441	Cleavage	31765674
Cross	ISG15	P05161	L	Crimean-Congo hemorrhagic fever virus	Q6TQR6	GMS	21245344
Cross	ISG15	P05161	L	Crimean-Congo hemorrhagic fever virus	Q6TQR6	Cleavage	21245344
Cross	ISG15	P05161	L	Crimean-Congo hemorrhagic fever virus	Q6TQR6	Ion Exchange Chrom	21245344
Cross	ISG15	P05161	L	Crimean-Congo hemorrhagic fever virus	Q6TQR6	X-Ray Diffraction	21245344

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ISG15 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P70149	ISG15/UCRP Protein, Human (His)	AAH09507.1 (G2-G157)	≥ 95%, as determined by reducing SDS-PAGE.

ISG15 Antibodies

Art. -Nr.	Produktname	Anwendung	Reactivity
HY-P80194	ISG15 Antibody (YA333)	WB	Human
HY-P86529	ISG15 Antibody (YA6221)	WB, ICC/IF, IP, ELISA	Human

Related Diseases

Diseases	Alias
Immunodeficiency 38 With Basal Ganglia Calcification	Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Isg15 Deficiency IMD38 Immunodeficiency 38, Mycobacteriosis, Autosomal Recessive Immunodeficiency 38 Isg15 Deficiency, Autosomal Recessive Immunodeficiency 38, With Basal Ganglia Calcification Autosomal Recessive Isg15 Deficiency Msmd Due To Complete Isg15 Deficiency Immunodeficiency, Type 38
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Crimean-Congo Hemorrhagic Fever	Crimean Hemorrhagic Fever Cchf Congo Hemorrhagic Fever Hemorrhagic Fever, Crimean Chf Congo Virus Congo-Crimean Hemorrhagic Fever Congo Fever Hemorrhagic Fever Crimean-Congo Cchf - [Crimean-Congo Haemorrhagic Fever] Kara Mikh Typhoid Fever Xīnjiāng Haemorrhagic Fever
Basal Ganglia Calcification	Fahr'S Syndrome Fahr'S Disease Fahr Disease
Middle East Respiratory Syndrome	Mers Mers - [Middle East Respiratory Syndrome]
Torch Syndrome
Hepatitis E
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Immunodeficiency 44	IMD44
Bladder Cancer	Urinary Bladder Cancer Bladder Carcinoma Urinary Bladder Carcinoma Bladder Neoplasm Bladder Tumor Cancer, Bladder Malignant Neoplasm Of Urinary Bladder Carcinoma Of Bladder Bladder Cancer, Somatic Tumor Of The Bladder Carcinoma Of Urinary Bladder Bladder Carcinoma Urinary Cancer Of The Urinary Bladder Cancer, Urinary Bladder Malignant Bladder Neoplasm Malignant Bladder Tumor Neoplasm Of The Bladder Neoplasm Of The Urinary Bladder Tumor Of The Urinary Bladder Urinary Bladder Neoplasm BLC Urothelial Carcinoma Of The Bladder Bladder Tumors Urinary Bladder Neoplasms Bladder Cancer Nos Vesical Cancer Nos Malignant Neoplasm Of Bladder, Part Unspecified Malignant Tumour Of Urinary Bladder Primary Malignant Neoplasm Of Bladder
Adult Dermatomyositis	Adult Onset Dermatomyositis Adult Type Dermatomyositis
Sting-Associated Vasculopathy With Onset In Infancy	Savi Sting-Associated Vasculopathy, Infantile Onset Sting-Associated Vasculopathy, Infantile-Onset
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Ebola Hemorrhagic Fever	Ebola Virus Disease Viral Hemorrhagic Fever Hemorrhagic Fever, Ebola Ebola Ehf Ebola Fever Hemorrhagic Fevers, Viral Ebola Haemorrhagic Fever Ebod - [Ebola Disease] Evd - [Ebola Virus Disease] Ebola Virus Haemorrhagic Fever Vhf - [Viral Haemorrhagic Fever] Nos Viral Haemorrhagic Fever, Not Otherwise Specified
Chilblain Lupus 1	Chilblain Lupus CHBL1 Chilblain Lupus Erythematosus Chle Hutchinson Lupus Chilblain Lupus, Type 1
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Immunodeficiency 27b	Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Ifngammar1 Deficiency IMD27B Immunodeficiency 27b, Mycobacteriosis, Autosomal Dominant Ifngr1 Deficiency, Autosomal Dominant Autosomal Dominant Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Interferon Gamma Receptor 1 Deficiency Autosomal Dominant Msmd Due To Partial Ifngammar1 Deficiency Autosomal Dominant Msmd Due To Partial Interferon Gamma Receptor 1 Deficiency Immunodeficiency 27b, Mycobacteriosis, Ad Autosomal Dominant Ifngr1 Deficiency Autosomal Dominant Immunodeficiency 27b, Mycobacteriosis Immunodeficiency, Type 27b, Mycobacteriosis, Autosomal Dominant
Vasculopathy, Retinal, With Cerebral Leukoencephalopathy And Systemic Manifestations	Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations Crv Rvcl Rvcl-S Vasculopathy, Retinal, With Cerebral Leukodystrophy Retinopathy, Vascular, With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena Retinal Vasculopathy With Cerebral Leukodystrophy Retinal Vasculopathy And Cerebral Leukoencephalopathy Hereditary Vascular Retinopathy Hvr RVCLS Cerebroretinal Vasculopathy, Hereditary Cerebroretinal Vasculopathy Herns Vasculopathy, Retinal, With Cerebral Leukodystrophy, Formerly Hereditary Cerebroretinal Vasculopathy Hereditary Endotheliopathy, Retinopathy, Nephropathy, Stroke Hereditary Systemic Angiopathy Hsa Retinal Vasculopathy With Cerebral Leukodystrophy With Systemic Manifestations Adrvcl Autosomal Dominant Retinal Vasculopathy With Cerebral Leukodystrophy Hereditary Endotheliopathy With Retinopathy-Nephropathy-Stroke Vascular Retinopathy With Cerebral And Renal Involvement And Raynaud And Migraine Phenomena
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-172969	ZHAWOC8655	Inhibitor	98.63%	Unkown
HY-152956	STING agonist-23	Agonist	99.33%	Unkown
HY-173425	STING-IN-15	Inhibitor	99.04%	Unkown
HY-152959	STING agonist-26	Agonist	99.56%	Unkown
HY-RS06929	ISG15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17041	Isg15 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-152957	STING agonist-24	Agonist	/	Unkown
HY-152958	STING agonist-25	Agonist	/	Unkown
HY-152961	STING agonist-28	Agonist	/	Unkown
HY-172193	UBD1031	Antagonist	/	Unkown
HY-174663	Human IFNE mRNA		/	Unkown
HY-RS23485	Isg15 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ISG15	VGNC	VGNC:42106
Bos taurus	ISG15	VGNC	VGNC:30293
Mus musculus	ISG15	MGD	MGI:1855694
Rattus norvegicus	ISG15	RGD	RGD:1310312
Macaca mulatta	ISG15	VGNC	VGNC:73697
Felis catus	ISG15	VGNC	VGNC:80247
Others	ISG15	NCBI