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Art. -Nr.: HY-126939

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MN-05

MN-05 is a dual neuroprotective and vasodilatory NMDA receptor inhibitor.MN-05 blocks calcium influx, reduces free radical production, and maintains mitochondrial membrane potential in cortical neurons exposed to glutamate.MN-05 dilates aortic rings against phenylephrine-induced contraction.MN-05 protects neurons against glutamate-induced injury in vitro.MN-05 can be used for the research of neurodegenerative diseases.

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CAS. Nr.: 1835197-63-1
Formel: C₁₃H₂₂N₂O₃
Molecular Weight:254.33

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Please store the product under the recommended conditions in the Certificate of Analysis.

MN-05 Chemical Structure

CAS. Nr.: 1835197-63-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
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Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

NMDA Receptor

Alle Calcium Channel Isoform-spezifische Produkte anzeigen :

Alle iGluR Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
Cerebellar granule neurone	EC₅₀	10.68 μM Compound: MN-05	Neuroprotective activity against glutamate-induced excitotoxicity in mouse primary cerebellar granule neurons assessed as increase in cell viability preincubated for 2 hrs followed by glutamate challenge measured after 24 hrs by MTT assay Neuroprotective activity against glutamate-induced excitotoxicity in mouse primary cerebellar granule neurons assessed as increase in cell viability preincubated for 2 hrs followed by glutamate challenge measured after 24 hrs by MTT assay	[PMID: 30108699]

In Vitro

MN-05 (0.1-100 μM; 24 h) potently protects primary cerebellar granule neurons against glutamate-induced injury, with an EC₅₀ of 10.68 μM^[1].
MN-05 (5-45 μM; 24 h) protects primary rat cortical neurons against glutamate-induced injury in vitro in a concentration-dependent manner^[1].
MN-05 (5-15 μM; 5 min) inhibits glutamate-induced intracellular calcium influx in primary cortical neurons^[1].
MN-05 (5-45 μM; 12 h) concentration-dependently inhibits the production of reactive oxygen/nitrogen species in primary cortical neurons induced by glutamate^[1].
MN-05 (5-45 μM; 12 h) maintains mitochondrial membrane potential in a concentration-dependent manner and inhibits glutamate-induced mitochondrial dysfunction in primary cortical neurons^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1835197-63-1
Molecular Weight 254.33
Formel C₁₃H₂₂N₂O₃
SMILES

NC(C1)(CC(C2)(C3)CC)CC2CC13CO[N+]([O-])=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Liu Z, et al. Synthesis and biological evaluation of memantine nitrates as a potential treatment for neurodegenerative diseases. Medchemcomm. 2016;8(1):135-147. Published 2016 Oct 20. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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MN-05

Alle Calcium Channel Isoform-spezifische Produkte anzeigen

Alle iGluR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

MN-05 Related Classifications

HY-126939 Related Classifications