1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. AZD 2066 hydrate

AZD 2066 hydrate 

Cat. No.: HY-110255A
Handling Instructions

AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 hydrate has antinociception effects.

For research use only. We do not sell to patients.

AZD 2066 hydrate Chemical Structure

AZD 2066 hydrate Chemical Structure

Size Price Stock Quantity
5 mg USD 585 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 hydrate has antinociception effects[1].

IC50 & Target[1]



In Vitro

AZD 2066 (1-10 μM) inhibits Ca2+ response, with IC50s of 27.2±9.1, 3.56±0.52, 96.2±17.8, and 380±78.0 nM in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures respectively[2].
AZD 2066 (1-10 μM) inhibits the oscillatory Ca2+ response which induced by bath application of DHPG, and blocks either DHPG or Quis effects in mGlu5/HEK cells[2].
AZD 2066 (1-10 μM) has less effective in striatal neurons[2].

In Vivo

AZD 2066 (0.03-30 mg/kg; p.o.) shows discriminative effects in rats[1].

Animal Model: Male Wistar rats (weighing 240-250 g)[1]
Dosage: 0.03, 0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration: P.o. (60 minutes after administration)
Result: Caused full and dose-dependent AZD9272-appropriate responding.
Molecular Weight





CN1C(C2=CC=NC=C2)=NN=C1O[[email protected]@H](C3=NOC(C4=CC(Cl)=CC=C4)=C3)C.O.[1/4]


Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

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AZD 2066AZD2066AZD-2066mGluRMetabotropic glutamate receptorsmGluR5antinociceptionInhibitorinhibitorinhibit

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