2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. AZD 2066 hydrate

AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 hydrate has antinociception effects.

For research use only. We do not sell to patients.

AZD 2066 hydrate Chemical Structure

AZD 2066 hydrate Chemical Structure

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AZD 2066 hydrate Related Antibodies

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1 Publications Citing Use of MCE AZD 2066 hydrate

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Description

AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 hydrate has antinociception effects[1].

IC50 & Target[1]

mGluR5

 

In Vitro

AZD 2066 (1-10 μM) inhibits Ca2+ response, with IC50s of 27.2±9.1, 3.56±0.52, 96.2±17.8, and 380±78.0 nM in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures respectively[2].
AZD 2066 (1-10 μM) inhibits the oscillatory Ca2+ response which induced by bath application of DHPG, and blocks either DHPG or Quis effects in mGlu5/HEK cells[2].
AZD 2066 (1-10 μM) has less effective in striatal neurons[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AZD 2066 hydrate Related Antibodies
In Vivo

AZD 2066 (0.03-30 mg/kg; p.o.) shows discriminative effects in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (weighing 240-250 g)[1]
Dosage: 0.03, 0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration: P.o. (60 minutes after administration)
Result: Caused full and dose-dependent AZD9272-appropriate responding.
Clinical Trial
Molecular Weight

386.33

Formula

C19H16ClN5O2.1/4H2O
Appearance

Solid

Color

Off-white to light yellow

SMILES

CN1C(C2=CC=NC=C2)=NN=C1O[C@@H](C3=NOC(C4=CC(Cl)=CC=C4)=C3)C.O.[1/4]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥99.0%

COA (248 KB)

Handling Instructions (2659 KB)
References
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AZD 2066 hydrate Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZD 2066AZD2066AZD-2066mGluRMetabotropic glutamate receptorsmGluR5antinociceptionInhibitorinhibitorinhibit

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AZD 2066 hydrate
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HY-110255A
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