1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. AZD 2066 hydrate

AZD 2066 hydrate 

Cat. No.: HY-110255A Purity: >99.0%
Handling Instructions

AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 hydrate has antinociception effects.

For research use only. We do not sell to patients.

AZD 2066 hydrate Chemical Structure

AZD 2066 hydrate Chemical Structure

Size Price Stock Quantity
5 mg USD 585 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 hydrate has antinociception effects[1].

IC50 & Target[1]

mGluR5

 

In Vitro

AZD 2066 (1-10 μM) inhibits Ca2+ response, with IC50s of 27.2±9.1, 3.56±0.52, 96.2±17.8, and 380±78.0 nM in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures respectively[2].
AZD 2066 (1-10 μM) inhibits the oscillatory Ca2+ response which induced by bath application of DHPG, and blocks either DHPG or Quis effects in mGlu5/HEK cells[2].
AZD 2066 (1-10 μM) has less effective in striatal neurons[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AZD 2066 (0.03-30 mg/kg; p.o.) shows discriminative effects in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (weighing 240-250 g)[1]
Dosage: 0.03, 0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration: P.o. (60 minutes after administration)
Result: Caused full and dose-dependent AZD9272-appropriate responding.
Clinical Trial
Molecular Weight

386.33

Formula

C₁₉H₁₆ClN₅O₂.₁/₄H₂O

SMILES

CN1C(C2=CC=NC=C2)=NN=C1O[[email protected]@H](C3=NOC(C4=CC(Cl)=CC=C4)=C3)C.O.[1/4]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: >99.0%

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Keywords:

AZD 2066AZD2066AZD-2066mGluRMetabotropic glutamate receptorsmGluR5antinociceptionInhibitorinhibitorinhibit

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Product Name:
AZD 2066 hydrate
Cat. No.:
HY-110255A
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