1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. AZD 2066

AZD 2066 

Cat. No.: HY-110255 Purity: >99.0%
Handling Instructions

AZD 2066 is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 has antinociception effects.

For research use only. We do not sell to patients.

AZD 2066 Chemical Structure

AZD 2066 Chemical Structure

CAS No. : 934282-55-0

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Description

AZD 2066 is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 has antinociception effects[1].

IC50 & Target[1]

mGluR5

 

In Vitro

AZD 2066 (1-10 μM) inhibits Ca2+ response, with IC50s of 27.2±9.1, 3.56±0.52, 96.2±17.8, and 380±78.0 nM in mGlu5/HEK cells and striatal, hippocampal, and cortical cultures respectively[2].
AZD 2066 (1-10 μM) inhibits the oscillatory Ca2+ response which induced by bath application of DHPG, and blocks either DHPG or Quis effects in mGlu5/HEK cells[2].
AZD 2066 (1-10 μM) has less effective in striatal neurons[2].

In Vivo

AZD 2066 (0.3-30 mg/kg; p.o.) shows discriminative effects in rats[1].

Animal Model: Male Wistar rats (weighing 240-250 g)[1]
Dosage: 0.03, 0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration: P.o. (60 minutes after administration)
Result: Caused full and dose-dependent AZD9272-appropriate responding.
Clinical Trial
Molecular Weight

381.82

Formula

C₁₉H₁₆ClN₅O₂

CAS No.

934282-55-0

SMILES

CN1C(C2=CC=NC=C2)=NN=C1O[[email protected]@H](C3=NOC(C4=CC(Cl)=CC=C4)=C3)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

AZD 2066AZD2066AZD-2066mGluRMetabotropic glutamate receptorsmGluR5antinociceptionInhibitorinhibitorinhibit

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AZD 2066
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