Beacon (47-73)
Beacon (47-73) is a C-terminal peptide fragment 47-73 of Beacon, and Beacon is a protein of 73 amino acid. Beacon (47-73) can be used for metabolic syndrome research.
For research use only. We do not sell to patients.
- CAS No.: 681153-68-4
- Formula: C156H217N35O46S
- Molecular Weight:3350.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
A 3-h exposure to Beacon (47-73) is ineffective, but prolonged (24 and 96 h) exposures significantly lowered basal corticosterone and cortisol secretion from cultured rat and human zona fasciculata/reticularis (ZF/R) cells, respectively. Moreover, Beacon (47-73) (400 nM) counteracted the secretagogue action of 10 nM ACTH on cultured cells. The 96-h exposure to Beacon (47-73) concentration-dependently decreases basal proliferation rate of cultured cells, without inducing significant changes in the number of apoptotic and necrotic cells. Beacon (400 nM) significantly inhibits the proliferogenic effect of 10 nM Adrenomedullin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 681153-68-4
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Molecular Weight 3350.66
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Formula C156H217N35O46S
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Sequence Shortening
WYTIFKDHVSLGDYEIHDGMNLELYYQ
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Agnieszka Ziolkowska, et al. Beacon[47-73] inhibits glucocorticoid secretion and growth of cultured rat and human adrenocortical cells. Int J Mol Med. 2004 Sep;14(3):457-61. [Content Brief]
[2]. Y K Ng, et al. Beacon immunoreactivity in the rat hypothalamus. J Neurosci Res. 2006 May 1;83(6):1106-17. [Content Brief]
[3]. Agnieszka Ziolkowska, et al. Expression of the beacon gene in endocrine glands of the rat. Peptides. 2004 Jan;25(1):133-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Beacon (47-73) Related Classifications
HY-P3829 Related Classifications
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