Bio-AMS TFA 

Bio-AMS (TFA) is a potent bacterial biotin protein ligase inhibitor. Bio-AMS (TFA) possesses selective activity against Mycobacterium tuberculosis (Mtb) and arrests fatty acid and lipid biosynthesis^[1].

Biotin protein ligase^[1]

Bio-AMS possesses excellent antitubercular activity against Mtb H37Rv and MDR/XDR-TB strains with MICs ranging from 0.16 to 0.625 μM and is not affected by changes to the primary carbon source^[1].
Bio-AMS (2.5, 5 and 10 μM; 24 h) inhibits growth of Mtb in a concentration-dependent manner in Mtb-infected mouse macrophages; shows no signs of mitochondrial toxicity^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

685.65

C₂₂H₃₀F₃N₉O₉S₂

Solid

White to off-white

O[C@H]([C@@H]1O)[C@@H](O[C@@H]1CNS(NC(CCCC[C@H]2[C@](NC3=O)([H])[C@](N3)([H])CS2)=O)(=O)=O)N4C5=NC=NC(N)=C5N=C4.OC(C(F)(F)F)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Bockman MR, Aldrich CC, et al. Avoiding Antibiotic Inactivation in Mycobacterium tuberculosis by Rv3406 through Strategic Nucleoside Modification. ACS Infect Dis. 2018 Jul 13;4(7):1102-1113.  [Content Brief]

  [2]. Tiwari D, Schnappinger D, et al. Targeting protein biotinylation enhances tuberculosis chemotherapy. Sci Transl Med. 2018 Apr 25;10(438):eaal1803.  [Content Brief]