2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. BMS-986308

BMS-986308 is a selective and orally active renal outer medullary potassium (ROMK) channel inhibitor. BMS-986308 is selective for ROMK over hERG. BMS-986308 can be used for heart failure research.

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BMS-986308

BMS-986308 Chemical Structure

CAS No. : 2254333-97-4

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Description

BMS-986308 is a selective and orally active renal outer medullary potassium (ROMK) channel inhibitor. BMS-986308 is selective for ROMK over hERG. BMS-986308 can be used for heart failure research[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
>100 μM
Compound: 28; BMS-986308
Cytotoxicity against human HepG2 cells
Cytotoxicity against human HepG2 cells
[PMID: 38807539]
In Vivo

BMS-986308 (0.01-3 mg/kg; p.o; once) demonstrates efficacy in the volume-loaded rat diuresis model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (age: 8-12 weeks, 270-300 g)[1]
Dosage: 0.01 mg/kg, 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg and 3 mg/kg
Administration: p.o; once (10% v/v DMAC, 40% v/v PEG400, 50% v/v of 30% w/v of HPβCD in 50 mM citrate buffer (pH 4.0))
Result: Led to a robust increase in diuresis.
Essai clinique
Masse moléculaire

443.50

Formule

C24H25N7O2
CAS No.
SMILES

CC1=C(COC2=O)C2=CC=C1[C@@H]3CN(C[C@@H](N3)C)CC4=NN(C5=CC(C)=C(C=N5)C#N)N=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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BMS-986308 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

BMS-9863082254333-97-4BMS986308BMS 986308Potassium ChannelKcsAROMK Inhibitororally activeheart failureInhibitorinhibitorinhibit

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