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Nfkbiz - nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta Gene

Also Known as INAP; Mail

Species: Mus musculus

Gene Type: protein coding

Gene ID: 80859

Summary

Involved in T cell receptor signaling pathway and positive regulation of T-helper 17 cell differentiation. Acts upstream of or within inflammatory response. Located in nucleus. Is expressed in early conceptus; eye; and genitourinary system. Used to study Stevens-Johnson syndrome and atopic dermatitis. Orthologous to human NFKBIZ (NFKB inhibitor zeta). [provided by Alliance of Genome Resources, Apr 2022]

Nfkbiz Products (3)

mRNA	Protein	Name
NM_001159394.1	NP_001152866.1	NF-kappa-B inhibitor zeta isoform a
NM_001159395.1	NP_001152867.1	NF-kappa-B inhibitor zeta isoform b
NM_030612.3	NP_085115.1	NF-kappa-B inhibitor zeta isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20383124	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	25107474	MGI
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	15618216	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in B cell proliferation	IMP IMP: Inferred from mutant phenotype	23728777	MGI
involved in B cell receptor apoptotic signaling pathway	IDA IDA: Inferred from direct assay	23728777	MGI
involved in B cell receptor signaling pathway	IDA IDA: Inferred from direct assay	17367755	MGI
involved in T cell differentiation	IMP IMP: Inferred from mutant phenotype	26019294	MGI
involved in T cell mediated immunity	IMP IMP: Inferred from mutant phenotype	31182790	MGI
involved in T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25282160	MGI
involved in T-helper 1 cell differentiation	IMP IMP: Inferred from mutant phenotype	31182790	MGI
involved in T-helper 17 cell differentiation	IMP IMP: Inferred from mutant phenotype	20383124	MGI
involved in adaptive immune response	IDA IDA: Inferred from direct assay	17367755	MGI
involved in cell growth	IMP IMP: Inferred from mutant phenotype	28740238	MGI
involved in cellular response to cytokine stimulus	IDA IDA: Inferred from direct assay	32144162	MGI
involved in cellular response to cytokine stimulus	IMP IMP: Inferred from mutant phenotype	26460049	MGI
involved in cellular response to interleukin-17	IDA IDA: Inferred from direct assay	31853061	MGI
involved in cellular response to interleukin-17	IMP IMP: Inferred from mutant phenotype	31164412	MGI
involved in cellular response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	27129283	MGI
involved in cellular response to transforming growth factor beta stimulus	IMP IMP: Inferred from mutant phenotype	26019294	MGI
involved in chemokine production	IMP IMP: Inferred from mutant phenotype	15491998	MGI
involved in chromatin organization	IMP IMP: Inferred from mutant phenotype	18319258	MGI
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	27129283	MGI
involved in chromatin remodeling	IMP IMP: Inferred from mutant phenotype	27129283	MGI
involved in chronic inflammatory response	IMP IMP: Inferred from mutant phenotype	31853061	MGI
involved in cytokine production	IMP IMP: Inferred from mutant phenotype	28740238	MGI
involved in cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	30224457	MGI
involved in defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	31182790	MGI
involved in epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	23453632	MGI
involved in establishment of skin barrier	IMP IMP: Inferred from mutant phenotype	28740238	MGI
involved in execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	26776679	MGI
involved in gene expression	IDA IDA: Inferred from direct assay	15618216	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	15491998	MGI
involved in homeostasis of number of cells within a tissue	IMP IMP: Inferred from mutant phenotype	26019294	MGI
involved in immunoglobulin mediated immune response	IMP IMP: Inferred from mutant phenotype	25124037	MGI
involved in immunoglobulin production	IMP IMP: Inferred from mutant phenotype	15491998	MGI
involved in immunoglobulin production involved in immunoglobulin-mediated immune response	IMP IMP: Inferred from mutant phenotype	18441309	MGI
acts upstream of or within inflammatory response	IDA IDA: Inferred from direct assay	11086164	MGI
involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	15491998	MGI
involved in inflammatory response to wounding	IDA IDA: Inferred from direct assay	26776679	MGI
involved in interleukin-10 production	IMP IMP: Inferred from mutant phenotype	27129283	MGI
involved in isotype switching	IMP IMP: Inferred from mutant phenotype	25124037	MGI
involved in keratinocyte activation	IMP IMP: Inferred from mutant phenotype	15491998	MGI
involved in keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	26460049	MGI
involved in keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	26460049	MGI
involved in lymphocyte activation involved in immune response	IMP IMP: Inferred from mutant phenotype	23453632	MGI
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	27129283	MGI
involved in mRNA transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	27129283	MGI
involved in plasma cell differentiation	IMP IMP: Inferred from mutant phenotype	25124037	MGI
involved in positive regulation of T-helper 17 cell differentiation	IMP IMP: Inferred from mutant phenotype	25282160	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	27129283	MGI
involved in regulation of immune response	IMP IMP: Inferred from mutant phenotype	26019294	MGI
involved in response to Gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	28740238	MGI
involved in response to cisplatin	IDA IDA: Inferred from direct assay	26776679	MGI
involved in response to cytokine	IMP IMP: Inferred from mutant phenotype	26776679	MGI
involved in response to folic acid	IDA IDA: Inferred from direct assay	26776679	MGI
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	26776679	MGI
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	31622280	MGI
involved in skin development	IMP IMP: Inferred from mutant phenotype	15491998	MGI
involved in skin epidermis development	IMP IMP: Inferred from mutant phenotype	15491998	MGI
involved in spleen development	IMP IMP: Inferred from mutant phenotype	31182790	MGI
involved in toll-like receptor signaling pathway	IDA IDA: Inferred from direct assay	23728777	MGI
involved in toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23728777	MGI
involved in transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20383124	MGI
involved in transcription preinitiation complex assembly	IMP IMP: Inferred from mutant phenotype	18319258	MGI
involved in type II interferon production	IMP IMP: Inferred from mutant phenotype	26019294	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in nucleus	IDA IDA: Inferred from direct assay	15618216	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11086164	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
NF-kappa-B inhibitor zeta	I-kappa-B-zeta IL-1 inducible nuclear ankyrin-repeat protein IkappaB-zeta ikB-zeta ikappaBzeta molecule possessing ankyrin-repeats induced by lipopolysaccharide

Nfkbiz Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Nfkbiz	Q9EST8	Akirin2	Mus musculus	B1AXD8	Anti Tag CoIP	25107474
Intra	Nfkbiz	Q9EST8	Akirin2	Mus musculus	B1AXD8	Anti Bait CoIP	25107474

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09265	NFKBIZ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nfkbiz	NCBI	NCBI:64332