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Cat. No.: HY-163441

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BChE-IN-31

BChE-IN-31 (Compound 14d) is a selective BChE inhibitor with an IC₅₀ of 65 nM. BChE-IN-31 inhibits the self-induced aggregation of neurotoxic amyloid-β (Aβ) peptide.

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Formule: C₃₁H₄₂N₄O
Masse moléculaire:486.69

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

BChE-IN-31 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

BChE-IN-31 (Compound 14d) is a selective BChE inhibitor with an IC₅₀ of 65 nM. BChE-IN-31 inhibits the self-induced aggregation of neurotoxic amyloid-β (Aβ) peptide^[1].

IC₅₀ & Target

BChE

65 nM (IC₅₀)

AChE

5.9 μM (IC₅₀)

Voir tous les produits spécifiques à Isoform Cholinesterase (ChE) :

AChE
BChE

Cellular Effect

Cell Line	Type	Value	Description	References
SH-SY5Y	IC₅₀	60 μM Compound: 14d	Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 38579622]

In Vitro

BChE-IN-31 (0-20 μM, 24 h) exhibits a protective effect against NMDA (HY-17551)-induced toxicity and H₂O₂-induced oxidation in SH-SY5Y cells at 5 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

SH-SY5Y
Concentration:

0-20 μM
Incubation Time:

24 h
Result:

Improved the cell viability at 5 μM, inhibited cell viability dose-dependently at 5-20 μM.

Chemical Information

Masse moléculaire 486.69
Formule C₃₁H₄₂N₄O
SMILES

O=C1NCCCC2=C1C3=CC=CC=C3N2CCCCCCCN4CCN(CCC5=CC=CC=C5)CC4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Samarelli F, et al., Novel 6-alkyl-bridged 4-arylalkylpiperazin-1-yl derivatives of azepino [4, 3-b] indol-1 (2H)-one as potent BChE-selective inhibitors showing protective effects against neurodegenerative insults[J]. European Journal of Medicinal Chemistry, 2024: 116353.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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BChE-IN-31

Voir tous les produits spécifiques à Isoform Cholinesterase (ChE)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

BChE-IN-31 Related Classifications

HY-163441 Related Classifications