DIBA-Cy5
DIBA-Cy5 is a fluorescent DIBA antagonist made up be DIBA-alkyne binding Cyanine5 fluorophores (Cy5) and polyethylene glycol (PEG) biomolecules. DIBA-Cy5 can serve as a fluorescent ligand, suitable for probe attachment through click chemistry. DIBA-Cy5 exerts a high binding affinity to type-2 mAChR (M2R) with the Kd value of 1.80 nM, can directly stain M2R receptors in the sinoatrial node of a mouse heart.
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- Formule: C69H89N11O12S3
- Masse moléculaire:1360.71
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
mAChR2 1.80 nM (Kd) |
mAChR1 104.5 nM (Kd) |
In Vitro
DIBA-Cy5 (0.01 nM-1 mM; 5 h) shows selective binding property for type-2 mAChR (M2R) over M1R, with Kd of 1.08 nM and 104.5 nM, respectively[1].
DIBA-Cy5 (10 nM; 3 h) exerts the competitive binding mode with orthosteric antagonist Atropine (HY-B1205)/allosteric modulator LY2119620 (HY-15885), indicating a dualsteric binding mode of the DIBA-type antagonist to M2R[1].
DIBA-Cy5 (50 nM; 16 h) results direct staining to M2R receptors in the sinoatrial node of a mouse heart. DIBA-Cy5 can be used binding assays that screen compounds for M2R as the receptor target[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Emission (Em)
668
Excitation (Ex)
647
Chemical Information
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Masse moléculaire 1360.71
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Formule C69H89N11O12S3
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SMILES
CC1(C2=CC(S(=O)([O-])=O)=CC=C2[N+](CCCCCC(NCCCN3C=C(N=N3)CCN4CCN(CC4)CCCCC5CCN(CC5)CC(N6C7=CC=CC=C7NC(C8=C6C=CC=C8)=O)=O)=O)=C1/C=C/C=C/C=C9N(C%10=C(C/9(C)C)C=C(C=C%10)S(=O)(O)=O)CCCS(=O)(O)=O)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DIBA-Cy5 Related Classifications
HY-151801 Related Classifications
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