Pdx1 - pancreatic and duodenal homeobox 1 Gene

Also Known as Ipf1; IDX-1; IPF-1; Mody4; STF-1; pdx-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18609

Summary

Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including negative regulation of apoptotic process; pancreas development; and regulation of transcription by RNA polymerase II. Located in nuclear speck. Is expressed in several structures, including gut; liver and biliary system; reproductive system; sensory organ; and skeleton. Used to study maturity-onset diabetes of the young; maturity-onset diabetes of the young type 4; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in cerebral infarction; hyperglycemia; maturity-onset diabetes of the young type 4; pancreatic agenesis; and type 2 diabetes mellitus. Orthologous to human PDX1 (pancreatic and duodenal homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Pdx1 Products (1)

mRNA Protein Name
NM_008814.4 NP_032840.1 pancreas/duodenum homeobox protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15486225 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12368292 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
19651901 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15121856 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
14701942 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
18155690 MGI
acts upstream of or within digestive tract development IMP
IMP: Inferred from mutant phenotype
19619492 MGI
acts upstream of or within endocrine pancreas development IMP
IMP: Inferred from mutant phenotype
18155690 MGI
acts upstream of or within enteroendocrine cell differentiation IMP
IMP: Inferred from mutant phenotype
16418487 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
18155690 MGI
acts upstream of or within exocrine pancreas development IMP
IMP: Inferred from mutant phenotype
16126192 MGI
acts upstream of or within glucose homeostasis IGI
IGI: Inferred from genetic interaction
20811152 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
18155690 MGI
acts upstream of or within glucose metabolic process IDA
IDA: Inferred from direct assay
12904469 MGI
acts upstream of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
20811152 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
19619492 MGI
acts upstream of or within morphogenesis of embryonic epithelium IMP
IMP: Inferred from mutant phenotype
8625829 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
18155690 MGI
acts upstream of or within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
20811152 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
18155690 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17056599 MGI
acts upstream of or within negative regulation of type B pancreatic cell apoptotic process IMP
IMP: Inferred from mutant phenotype
20811152 MGI
acts upstream of or within pancreas development IMP
IMP: Inferred from mutant phenotype
8625829 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12368292 MGI
involved in positive regulation of insulin secretion IDA
IDA: Inferred from direct assay
12219087 MGI
acts upstream of or within positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
22253604 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14701942 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19799567 MGI
acts upstream of or within positive regulation of type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
18155690 MGI
acts upstream of or within regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12488434 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14701942 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
12972592 MGI
acts upstream of type B pancreatic cell apoptotic process IMP
IMP: Inferred from mutant phenotype
20811152 MGI
acts upstream of or within type B pancreatic cell differentiation IMP
IMP: Inferred from mutant phenotype
16418487 MGI
acts upstream of type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
18155690 MGI
Cellular Component GO Annotation Evidence Références Source
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
10868931 MGI
located in nuclear speck IDA
IDA: Inferred from direct assay
15121856 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11287626 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pancreas/duodenum homeobox protein 1

  • insulin promoter factor 1, homeodomain transcription factor

  • islet/duodenum homeobox 1

  • pancreatic and duodenal homeobox gene 1

  • somatostatin-transactivating factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-19694 BRD7552 Activator 99.81% Unkown
HY-N0777 Isorhamnetin-3-O-glucoside 99.96% Unkown
HY-133668 Monoethyl phthalate Activator 98.58% Unkown
HY-133668S Monoethyl phthalate-d4 Activator 98.36% Unkown
HY-N19830 Guavenoic acid Inhibitor / Unkown
HY-RS10264 PDHX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10295 PDX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W1130459 (R)-C12-200 / Unkown
HY-174547 Human PDX1 mRNA / Unkown
HY-RS20792 Pdx1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21404 Pdhx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27306 Pdx1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P991294 MGTA-117 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdx1 NCBI NCBI:3651