TMSB4X - thymosin beta 4 X-linked Gene

Also Known as FX; TB4X; PTMB4; TMSB4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7114

About TMSB4X

Cytogenetic location: Xp22.2 Genomic coordinates (GRCh38): X:12,975,110-12,977,223 (from NCBI)

This gene has 4 transcripts (splice variants), 34 orthologues, 1 paralogue and is associated with 32 phenotypes. Broad expression in spleen (RPKM 3301.5), lymph node (RPKM 3201.4) and 24 other tissues.

Summary

This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]

TMSB4X Products (1)

mRNA Protein Name
NM_021109.4 NP_066932.1 thymosin beta-4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables actin monomer binding IDA
IDA: Inferred from direct assay
1447300 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
21106936 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17967441 GOA
enables protein sequestering activity IMP
IMP: Inferred from mutant phenotype
21343177 GOA
Biological Process GO Annotation Evidence Références Source
acts upstream of or within positive effect negative regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
21343177 GOA
involved in negative regulation of hematopoietic stem cell differentiation IDA
IDA: Inferred from direct assay
7694679 GOA
involved in negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
21343177 GOA
involved in positive regulation of ATP biosynthetic process IDA
IDA: Inferred from direct assay
21106936 GOA
involved in positive regulation of blood vessel endothelial cell migration IDA
IDA: Inferred from direct assay
21106936 GOA
involved in positive regulation of blood vessel endothelial cell migration IGI
IGI: Inferred from genetic interaction
21106936 GOA
involved in positive regulation of endothelial cell chemotaxis IDA
IDA: Inferred from direct assay
21106936 GOA
involved in positive regulation of proton-transporting ATP synthase activity, rotational mechanism IDA
IDA: Inferred from direct assay
21106936 GOA
involved in sequestering of actin monomers IDA
IDA: Inferred from direct assay
1447300 GOA
acts upstream of or within positive effect tumor necrosis factor-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
21343177 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21343177 GOA
located in cytosol IDA
IDA: Inferred from direct assay
1447300 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21343177 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMSB4X Protein Structure

Thymosin

Thymosin: Thymosin beta-4 family (2 - 41)

  • 0
  • 44 a.a.
Protein Preferred Names Protein Names

thymosin beta-4

  • prothymosin beta-4

TMSB4X Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
TMSB4X P62328 KRTAP8-1 Homo sapiens Q8IUC2
Validated Y2H
32296183
Intra
TMSB4X P62328 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Array
32296183
Intra
TMSB4X P62328 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Prey Pooling
32296183
Intra
TMSB4X P62328 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
TMSB4X P62328 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
TMSB4X P62328 KRT36 Homo sapiens O76013-2
Y2H Array
32296183
Intra
TMSB4X P62328 KRT36 Homo sapiens O76013-2
Y2H Prey Pooling
32296183
Intra
TMSB4X P62328 UHMK1 Homo sapiens Q8TAS1-2
Validated Y2H
32296183
Intra
TMSB4X P62328 UHMK1 Homo sapiens Q8TAS1-2
Y2H Prey Pooling
32296183
Intra
TMSB4X P62328 UHMK1 Homo sapiens Q8TAS1-2
Y2H Array
32296183
Intra
TMSB4X P62328 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
Intra
TMSB4X P62328 AKAP8L Homo sapiens Q9ULX6
Validated Y2H
32296183
Intra
TMSB4X P62328 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
Intra
TMSB4X P62328 COG6 Homo sapiens Q9Y2V7
Y2H Array
32296183
Intra
TMSB4X P62328 COG6 Homo sapiens Q9Y2V7
Y2H Prey Pooling
32296183
Intra
TMSB4X P62328 COG6 Homo sapiens Q9Y2V7
Validated Y2H
32296183
Intra
TMSB4X P62328 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
TMSB4X P62328 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
TMSB4X P62328 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
TMSB4X P62328 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
TMSB4X P62328 FHL3 Homo sapiens Q13643
Y2H Array
32296183
Intra
TMSB4X P62328 FHL3 Homo sapiens Q13643
Y2H Prey Pooling
32296183
Intra
TMSB4X P62328 FHL3 Homo sapiens Q13643
Validated Y2H
32296183
Intra
TMSB4X P62328 MLH1 Homo sapiens P40692
Anti Bait CoIP
17967441
Intra
TMSB4X P62328 MLH1 Homo sapiens P40692
Y2H
17967441
Intra
TMSB4X P62328 MLH1 Homo sapiens P40692
Anti Bait CoIP
20706999
Intra
TMSB4X P62328 MLH1 Homo sapiens P40692
Anti Tag CoIP
20706999
Intra
TMSB4X P62328 MLH1 Homo sapiens P40692
Confocal
17967441
Intra
TMSB4X P62328 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra
TMSB4X P62328 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
TMSB4X P62328 KRT31 Homo sapiens Q15323
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TMSB4X Proteins

Cat. No. Nom du produit Accession Pureté
HY-P72776 TMSB4X/Thymosin beta 4 Protein, Human P62328 (S2-S44) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P71930A TMSB4X/Thymosin beta 4 Protein, Human (His) P62328 (S2-S44) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Osteoarthritis

  • Osteoarthrosis

  • Degenerative Joint Disease

  • Hypertrophic Arthritis

  • Arthropathy

  • Degenerative Polyarthritis

  • Degenerative Arthritis

  • Osteoarthrosis And Allied Disorder

  • Arthritis, Degenerative

  • Oa

  • Osteoarthritis Deformans

  • Osteoarthrosis Deformans

  • Kashin-Beck Disease
Pulmonary Systemic Sclerosis

  • Lung Disease With Systemic Sclerosis

  • Lung Involvement In Systemic Sclerosis
Invasive Malignant Thymoma

  • Infiltrating Thymoma

  • Thymoma Malignant Invasive

  • Invasive Thymoma And Thymic Carcinoma
Thymoma

  • Primary Thymic Epithelial Neoplasm

  • Primary Thymic Epithelial Tumor

  • Thymus Neoplasms
Lateral Myocardial Infarction
Fibrosarcoma

  • Neoplasms, Fibrous Tissue

  • Fibrocytic Tumor

  • Fibrosarcoma Of Soft Tissue

  • Fibrous Tissue Neoplasm
Keratopathy
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Malignant Iris Melanoma

  • Malignant Melanoma Of Iris

  • Melanoma Of The Iris
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS14775 TMSB4X Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17930 Tmsb4x Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24400 Tmsb4x Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TMSB4X MGD MGI:99510
Rattus norvegicus TMSB4X RGD RGD:621622