HDAC6-IN-37
HDAC6-IN-37 (compound W5) is an inhibitor of HDAC6 and has neuroprotective effects. HDAC6-IN-37 can restore the morphology of hippocampal neurons, reduce the expression of Aβ, Tau, and p-Tau proteins in the hippocampus of AD rats, and inhibit the formation of senile plaques and neurofibrillary tangles. Thus, HDAC6-IN-37 improves the Aβ/Cu2+-induced AD model in rats, regulates oxidative stress status, and balances neurotransmitter disorders in brain tissue.
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- CAS No.: 2986486-82-0
- Formule: C19H16ClN3O2S
- Masse moléculaire:385.87
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SH-SY5Y | IC50 |
114.7 μM
Compound: W5
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Cytotoxicity against human SH-SY5Y cells assessed as cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as cell viability incubated for 24 hrs by MTT assay
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[PMID: 34517222] |
Chemical Information
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CAS No. 2986486-82-0
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Masse moléculaire 385.87
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Formule C19H16ClN3O2S
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SMILES
O=C(C1=CN=C(C=C1)CN2C3=CC=CC=C3SC4=C2C=CC=C4)NO.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC6-IN-37 Related Classifications
HY-158030 Related Classifications
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