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Cat. No.: HY-187630

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KNI-174

KNI-174 is a potent and selective HIV-1 protease inhibitor and antiviral agent. KNI-174 targets and inhibits HIV-1-specific aspartic protease, thereby blocking retroviral proliferation. KNI-174 can be used in research related to acquired immunodeficiency syndrome (AIDS).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 141804-42-4
Formule: C₃₆H₄₅N₅O₇S
Masse moléculaire:691.84

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

KNI-174 Chemical Structure

CAS No.: 141804-42-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- Parmacokinetics
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target

^[1]

HIV-1

Voir tous les produits spécifiques à Isoform HIV :

Cellular Effect

Cell Line	Type	Value	Description	References
ATH-8 cell line	IC50	276 ng/mL	HIV-1 antiviral activity against ATH8 cells, quantified as inhibition of HIV-1 replication. HIV-1 antiviral activity against ATH8 cells, quantified as inhibition of HIV-1 replication.	8490108

In Vitro

KNI-174 potently inhibits HIV-1 replication in the ATH8 cell line with an IC₅₀ of 276 ng/mL (0.40 μM)^[1].
KNI-174 potently inhibits HIV-1 replication in PHA-PBM with an IC₅₀ of 138 ng/mL (0.20 μM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2 (Elimination)	CL_total	V₁	V_dss	MRT	AUC_0-last	AUC_0-∞	T_1/2 (Distribution)
Rat^[1]	10.0 mg/kg	i.v.	3.97 h	9.53 mL/min	544 mL/kg	7070 mL/kg	3.14 h	4.42 μg·h/mL	4.80 μg·h/mL	5.07 min

Chemical Information

CAS No. 141804-42-4
Masse moléculaire 691.84
Formule C₃₆H₄₅N₅O₇S
SMILES

CC(C)(C)NC([C@H]1N(CSC1(C)C)C([C@@H](O)[C@@H](NC([C@H](CC(N)=O)NC(COC2=CC=CC3=C2C=CC=C3)=O)=O)CC4=CC=CC=C4)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Kiriyama A, et al. Pharmacokinetic study of a tripeptide HIV-1 protease inhibitor, KNI-174, in rats after intravenous and intraduodenal administrations. Biopharmaceutics & drug disposition. 1993 Apr;14(3):199-207.

[2]. Kiriyama A, et al. Comparison of a new orally potent tripeptide HIV-1 protease inhibitor (anti-AIDS drug) based on pharmacokinetic characteristics in rats after intravenous and intraduodenal administrations. Biopharmaceutics & drug disposition. 1993 Nov;14(8):697-707.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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