MPiN
MPiN is a KV1.3 potassium channel inhibitor. The IC50 values of MPiN for inhibiting Kv1.3 currents are 1.1 μM (at -90 mV) and 0.6 μM (at -35 mV). MPiN exhibits in vivo efficacy in a mouse psoriasis model. MPiN can be used for the research of psoriasis.
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- CAS No.: 108975-37-7
- Formule: C17H21NO
- Masse moléculaire:255.35
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK-293T | IC50 |
1.1 μM
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Inhibition of human KV1.3 channel currents in HEK293T cells held at -90 mV (predominantly closed state) assessed via whole-cell patch-clamp electrophysiology assay with acute perfusion of MPiN.
Inhibition of human KV1.3 channel currents in HEK293T cells held at -90 mV (predominantly closed state) assessed via whole-cell patch-clamp electrophysiology assay with acute perfusion of MPiN.
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2026.07.06.736759 |
| HEK-293T | IC50 |
0.6 μM
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Inhibition of human KV1.3 channel currents in HEK293T cells held at -35 mV (predominantly inactivated state) assessed via whole-cell patch-clamp electrophysiology assay with acute perfusion of MPiN.
Inhibition of human KV1.3 channel currents in HEK293T cells held at -35 mV (predominantly inactivated state) assessed via whole-cell patch-clamp electrophysiology assay with acute perfusion of MPiN.
|
2026.07.06.736759 |
In Vitro
MPiN (10 μM) potently and reversibly inhibits human KV1.3 channels expressed in HEK293T cells, with higher inhibitory potency for inactivated channels (IC50 = 0.6 μM) than for closed channels (IC50 = 1.1 μM)[1].
MPiN (10 μM; 5 min) selectively inhibits human KV1.3 channels expressed in HEK293T cells, and acts only after the channels open[1].
MPiN (5-20 μM) allosterically promotes voltage sensor activation of human KV1.3 channels expressed in HEK293T cells, while inhibiting channel currents and inducing a hyperpolarizing shift in the activation curve without altering steady-state inactivation[1].
MPiN binds to a novel extracellular pocket formed by the PP1-PP2 turret loop, pore helix, and outer S5/S6 helices on human KV1.3[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c (male, 5-6 weeks old, imiquimod-induced psoriasis model)[1]
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Dosage:25 mg/kg
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Administration:i.p.; once daily for 10 days
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Result:Significantly reduced total Psoriasis Area and Severity Index scores.
Reduced spleen index.
Suppressed serum TNF-α levels.
Attenuated epidermal thickening.
Chemical Information
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CAS No. 108975-37-7
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Masse moléculaire 255.35
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Formule C17H21NO
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SMILES
OC1=C(CN2CCCCC2C)C3=CC=CC=C3C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MPiN Related Classifications
HY-187707 Related Classifications
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