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Cat. No.: HY-187134

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mTOR-IN-31

mTOR-IN-31 is a selective mTOR inhibitor with an IC₅₀ of 0.9 nM. mTOR-IN-31 inhibits the proliferation of prostate cancer cells. mTOR-IN-31 is applicable for cancer-related research.

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CAS No.: 1144075-32-0
Formule: C₂₀H₂₁N₅O₂S
Masse moléculaire:395.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

mTOR-IN-31 Chemical Structure

CAS No.: 1144075-32-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

mTOR-IN-31 is a selective mTOR inhibitor with an IC₅₀ of 0.9 nM. mTOR-IN-31 inhibits the proliferation of prostate cancer cells. mTOR-IN-31 is applicable for cancer-related research^[1].

IC₅₀ & Target^[1]

mTOR

0.9 nM (IC₅₀)

PI3Kα

423 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform mTOR :

Voir tous les produits spécifiques à Isoform PI3K :

In Vitro

mTOR-IN-31 (compound 9a) potently inhibits recombinant mTOR with an IC₅₀ of 0.9 nM, and exhibits over 1000-fold selectivity against recombinant PI3K-α^[1].
mTOR-IN-31 inhibits the proliferation of human prostate cancer cell line LNCaP (IC₅₀ = 85 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1144075-32-0
Masse moléculaire 395.48
Formule C₂₀H₂₁N₅O₂S
SMILES

O=C(NC)NC1=CC=C(C2=NC3=C(C(N4CC5OC(CC5)C4)=N2)SC=C3)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Verheijen J C, et al. Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabicyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. Bioorg Med Chem Lett, 2010, 20(1): 375-379.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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mTOR-IN-31

Voir tous les produits spécifiques à Isoform mTOR

Voir tous les produits spécifiques à Isoform PI3K

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

mTOR-IN-31 Related Classifications

HY-187134 Related Classifications