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Cat. No.: HY-103491

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PF-06462894

PF-06462894 is an alkyne-lacking metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator profiled in both rat and nonhuman primates.

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CAS No.: 1622291-66-0
Formule: C₁₈H₂₃N₃O₃
Masse moléculaire:329.39

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

PF-06462894 Chemical Structure

CAS No.: 1622291-66-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

PF-06462894 is an alkyne-lacking metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator profiled in both rat and nonhuman primates^[1].

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Chemical Information

CAS No. 1622291-66-0
Masse moléculaire 329.39
Formule C₁₈H₂₃N₃O₃
SMILES

O=C1C=C(OCC2=CC=CC=N2)N=C3N1[C@H](CC(C)(C)C)COC3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Antonia F. Stepan, et al. Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates. J. Med. Chem. 2017, 60, 18, 7764–7780

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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PF-06462894

Voir tous les produits spécifiques à Isoform iGluR

Activité biologique

Description

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PF-06462894 Related Classifications

HY-103491 Related Classifications

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Keywords

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