VU0155056
VU0155056 is a cell-permeable phospholipase D inhibitor.
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- CAS No.: 1130067-18-3
- Formule: C25H26N4O2
- Masse moléculaire:414.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Calu-1 | IC50 |
21 nM
Compound: 2
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Inhibition of human PLD1 in Calu1 cells
Inhibition of human PLD1 in Calu1 cells
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[PMID: 19268584] |
| Calu-1 | IC50 |
21 nM
Compound: 56
|
Inhibition of PLD1 in human Calu-1 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis
Inhibition of PLD1 in human Calu-1 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis
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[PMID: 19136975] |
| HEK293 | IC50 |
380 nM
Compound: 2
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Inhibition of GFP-labelled human PLD2 HEK293 cells
Inhibition of GFP-labelled human PLD2 HEK293 cells
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[PMID: 19268584] |
| HEK293 | IC50 |
380 nM
Compound: 56
|
Inhibition of GFP-tagged human PLD2 expressed in human HEK293 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis
Inhibition of GFP-tagged human PLD2 expressed in human HEK293 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis
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[PMID: 19136975] |
Chemical Information
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CAS No. 1130067-18-3
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Masse moléculaire 414.51
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Formule C25H26N4O2
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SMILES
O=C(NCCN1CCC(N2C(=O)NC=3C=CC=CC32)CC1)C=4C=CC=5C=CC=CC5C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Tsai YR, et al. Inhibition of formyl peptide-stimulated phospholipase D activation by Fal-002-2 via blockade of the Arf6, RhoA and protein kinase C signaling pathways in rat neutrophils. Naunyn Schmiedebergs Arch Pharmacol. 2013 Jun;386(6):507-19. [Content Brief]
[2]. McDavid S, Bauer MB, Brindley RL, Jewell ML, Currie KP. Butanol isomers exert distinct effects on voltage-gated calcium channel currents and thus catecholamine secretion in adrenal chromaffin cells. PLoS One. 2014;9(10):e109203. Published 2014 Oct 2. [Content Brief]
[3]. Tsai YR, Huang LJ, Lin HY, et al. Inhibition of formyl peptide-stimulated phospholipase D activation by Fal-002-2 via blockade of the Arf6, RhoA and protein kinase C signaling pathways in rat neutrophils. Naunyn Schmiedebergs Arch Pharmacol. 2013;386(6):507-519. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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