100234-62-6
Chemical Structure
Picrasidine J
- CAS No.: 100234-62-6
- Formula:C14H14N2O2
- Molecular Weight:242.27
InChIKey: BKAUNKSTECWQGT-UHFFFAOYSA-N
SMILES: OC1=CC=CC2=C1NC3=C2C(OC)=CN=C3CC
Biological Activity: Picrasidine J is a selective inhibitor targeting the KLK-10 protease and the ERK signaling pathway. Picrasidine J inhibits epithelial-mesenchymal transition (EMT) by upregulating E-Cadherin and ZO-1 and downregulating β-catenin and Snail, while simultaneously reducing KLK-10 expression and inhibiting ERK phosphorylation, thereby exhibiting significant anti-migratory and anti-invasive activity. Picrasidine J can inhibit the metastasis of head and neck squamous cell carcinoma (HNSCC) and is primarily used in anti-metastasis research for head and neck tumors[1][2].
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Picrasidine J | Picrasidine J is a selective inhibitor targeting the KLK-10 protease and the ERK signaling pathway. Picrasidine J inhibits epithelial-mesenchymal transition (EMT) by upregulating E-Cadherin and ZO-1 and downregulating β-catenin and Snail, while simultaneously reducing KLK-10 expression and inhibiting ERK phosphorylation, thereby exhibiting significant anti-migratory and anti-invasive activity. Picrasidine J can inhibit the metastasis of head and neck squamous cell carcinoma (HNSCC) and is primarily used in anti-metastasis research for head and neck tumors. | |||||||||||||||||||||
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- [1]. OHMOTO T, et al. Studies on the alkaloids from Picrasma quassioides bennet. VI. Structures of picrasidines N, O, and Q[J]. Chemical and pharmaceutical bulletin, 1985, 33(11): 4901-4905.
- [2]. Ho HY, et al. Picrasidine J, a Dimeric β-Carboline-Type Alkaloid from Picrasma quassioides, Inhibits Metastasis of Head and Neck Squamous Cell Carcinoma. Int J Mol Sci. 2023 Aug 25;24(17):13230. [Content Brief]
Keywords
