1005288-15-2
Chemical Structure
β-catenin-IN-3
- CAS No.: 1005288-15-2
- Formula:C19H20Br2N2OS
- Molecular Weight:484.25
IUPAC Name: (E)-1-(3,5-dibromo-2-hydroxystyryl)-3-(3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-5-yl)thiourea
InChIKey: VPOJWIBWEJWBKC-SNAWJCMRSA-N
SMILES: S=C(N/C=C/C(C=C1Br)=C(C(Br)=C1)O)NC(C2)C3C(C=CC4)C4C2C3
Biological Activity: β-catenin-IN-3 (Compound C2) is a selective β-catenin inhibitor. β-catenin-IN-3 binds to allosteric site on the surface of β-catenin with K D calculated at 54.96 nM. β-catenin-IN-3 selectively inhibits β-catenin via targeting a cryptic allosteric modulation site, lowers its cellular load. β-catenin-IN-3 significantly reduces viability of β-catenin driven cancer cells, and triggers β-catenin degradation via proteasome system in β-catenin-overexpressing cancer cells[1].
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β-catenin-IN-3 | 95.64% | β-catenin-IN-3 (Compound C2) is a selective β-catenin inhibitor. β-catenin-IN-3 binds to allosteric site on the surface of β-catenin with K D calculated at 54.96 nM. β-catenin-IN-3 selectively inhibits β-catenin via targeting a cryptic allosteric modulation site, lowers its cellular load. β-catenin-IN-3 significantly reduces viability of β-catenin driven cancer cells, and triggers β-catenin degradation via proteasome system in β-catenin-overexpressing cancer cells. | ||||||||||||||||||||
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Keywords
