1015439-77-6
Chemical Structure
AX-9657
- CAS No.: 1015439-77-6
- Formula:C22H26N4O3
- Molecular Weight:394.47
IUPAC Name: (S)-2-(2-(3-(dimethylamino)pyrrolidin-1-yl)pyridin-3-yl)-5-ethyl-7-methoxy-4H-benzo[d][1,3]oxazin-4-one
InChIKey: RCPIMTCZGQJSGZ-HNNXBMFYSA-N
SMILES: O=C1OC(C2=CC=CN=C2N3C[C@@H](N(C)C)CC3)=NC4=CC(OC)=CC(CC)=C14
Biological Activity: KRP-109 is a neutrophil elastase (NE) inhibitor with activity in reducing lung inflammation. KRP-109 improves survival in mouse models and reduces the number of neutrophils and inflammation in the alveolar walls. KRP-109 significantly reduced cell and neutrophil counts in bronchoalveolar lavage fluid, as well as cytokine levels such as interleukin 1β and macrophage inflammatory protein 2. KRP-109 can be used in the research of severe pneumonia[1].
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AX-9657 | KRP-109 is a neutrophil elastase (NE) inhibitor with activity in reducing lung inflammation. KRP-109 improves survival in mouse models and reduces the number of neutrophils and inflammation in the alveolar walls. KRP-109 significantly reduced cell and neutrophil counts in bronchoalveolar lavage fluid, as well as cytokine levels such as interleukin 1β and macrophage inflammatory protein 2. KRP-109 can be used in the research of severe pneumonia. | |||||||||||||||||||||
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Keywords
