101961-60-8
Chemical Structure
Valanimycin
- CAS No.: 101961-60-8
- Formula:C7H12N2O3
- Molecular Weight:172.18
IUPAC Name: (Z)-2-(1-carboxyvinyl)-1-isobutyldiazene 1-oxide
InChIKey: DTXMRELKPKEPSO-HJWRWDBZSA-N
SMILES: CC(C)C/[N+]([O-])=N/C(C(O)=O)=C
Biological Activity: Valanimycin is an antibiotic, which inhibits Escherichia coli (BE1121) through interaction with DNA. Valanimycin exhibits cytotoxicity to mouse leukemia L1210, P388/S (doxorubicin (HY-15142A)-sensitive), and P388/ADR (doxorubicin-resistant), with IC50 of 0.79, 2.65, and 1.44 μg/mL, respectively. Valanimycin exhibits antitumor efficacy against ehrlich ascites tumors or L1210 in mice[1].
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Valanimycin | Valanimycin is an antibiotic, which inhibits Escherichia coli (BE1121) through interaction with DNA. Valanimycin exhibits cytotoxicity to mouse leukemia L1210, P388/S (doxorubicin (HY-15142A)-sensitive), and P388/ADR (doxorubicin-resistant), with IC50 of 0.79, 2.65, and 1.44 μg/mL, respectively. Valanimycin exhibits antitumor efficacy against ehrlich ascites tumors or L1210 in mice. | |||||||||||||||||||||
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Keywords
